Radioactive Seed Localization for Nonpalpable Breast Lesions: Systematic Review and Meta-Analysis

This study is a systematic review with meta-analysis comparing radioactive seed localization (RSL) versus radio-guided occult lesion localization (ROLL) and wire-guided localization (WGL) for patients with impalpable breast cancer undergoing breast-conserving surgery and evaluating efficacy, safety,...

Full description

Saved in:
Bibliographic Details
Published in:Diagnostics (Basel) 2024-02, Vol.14 (4), p.441
Main Authors: Ferreira, Hortência H J, de Souza, Carla Daruich, Pozzo, Lorena, Ribeiro, Martha S, Rostelato, Maria Elisa C M
Format: Article
Language:English
Subjects:
Analysis
Bias
Breast cancer
Breast surgery
breast-conserving surgery
Cancer therapies
Intervention
intraoperative localization
Iodine
Localization
Lumpectomy
Mammography
Medical research
Medicine, Experimental
meta-analysis
Radiation
radioactive seed localization
Seeds
Systematic review
Ultrasonic imaging
Womens health
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:This study is a systematic review with meta-analysis comparing radioactive seed localization (RSL) versus radio-guided occult lesion localization (ROLL) and wire-guided localization (WGL) for patients with impalpable breast cancer undergoing breast-conserving surgery and evaluating efficacy, safety, and logistical outcomes. The protocol is registered in PROSPERO with the number CRD42022299726. A search was conducted in the Embase, Lilacs, Pubmed, Scielo, Web of Science, and clinicaltrials.gov databases, in addition to a manual search in the reference list of relevant articles, for randomized clinical trials and cohort studies. Studies selected were submitted to their own data extraction forms and risk of bias analysis according to the ROB 2 and ROBINS 1 tools. A meta-analysis was performed, considering the random effect model, calculating the relative risk or the mean difference for dichotomous or continuous data, respectively. The quality of the evidence generated was analyzed by outcome according to the GRADE tool. Overall, 46 articles met the inclusion criteria and were included in this systematic review; of these, 4 studies compared RSL and ROLL with a population of 1550 women, and 43 compared RSL and WGL with a population of 19,820 women. The results showed that RSL is a superior method to WGL in terms of surgical efficiency in the impalpable breast lesions' intraoperative localization, and it is at least equivalent to ROLL. Regarding security, RSL obtained results equivalent to the already established technique, the WGL. In addition to presenting promising results, RSL has been proven to be superior to WGL and ROLL technologies.
ISSN:2075-4418
2075-4418
DOI:10.3390/diagnostics14040441