Peripapillary choroidal vascularity index and thickness in patients with systemic sclerosis

IntroductionPatients with systemic sclerosis (SSc) present an increased risk of developing glaucomatous optic neuropathy (GON). We investigated peripapillary choroidal parameters and peripapillary retinal nerve fiber layer (RNFL) thickness using spectral domain optical coherence tomography (SD-OCT)...

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Published in:Frontiers in medicine 2023-10, Vol.10, p.1273438-1273438
Main Authors: Pieklarz, Barbara, Gińdzieńska-Sieśkiewicz, Ewa, Zawadzka, Izabela, Bagrowska, Magdalena, Daniluk, Joanna, Sidorczuk, Patryk, Kowal-Bielecka, Otylia, Konopińska, Joanna, Dmuchowska, Diana Anna
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choroidal vascularity index
glaucomatous optic neuropathy
Medicine
peripapillary choroidal thickness
retinal nerve fiber layer
systemic sclerosis
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container_title Frontiers in medicine
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creator Pieklarz, Barbara
Gińdzieńska-Sieśkiewicz, Ewa
Zawadzka, Izabela
Bagrowska, Magdalena
Daniluk, Joanna
Sidorczuk, Patryk
Kowal-Bielecka, Otylia
Konopińska, Joanna
Dmuchowska, Diana Anna
description IntroductionPatients with systemic sclerosis (SSc) present an increased risk of developing glaucomatous optic neuropathy (GON). We investigated peripapillary choroidal parameters and peripapillary retinal nerve fiber layer (RNFL) thickness using spectral domain optical coherence tomography (SD-OCT) to determine the relationships of these factors with clinical variables.MethodsA total of 33 patients with SSc were enrolled and compared to 40 controls. After obtaining circular scans around the optic disc, the global and quadrant peripapillary choroidal thickness (pCT) and RNFL thickness were measured. Additionally, the peripapillary choroidal vascularity index (pCVI), which allows for a quantitative analysis of the choroidal vasculature, was determined.ResultsNo significant differences were found in pCT and RNFL thickness between patients with SSc and controls, or within SSc subtypes (diffuse cutaneous systemic sclerosis (dcSSc) compared to limited cutaneous systemic sclerosis (lcSSc)) (p > 0.05). The pCVI was significantly lower in patients with SSc than in control subjects (64.25 ± 1.94 vs.65.73 ± 2.12, p 
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We investigated peripapillary choroidal parameters and peripapillary retinal nerve fiber layer (RNFL) thickness using spectral domain optical coherence tomography (SD-OCT) to determine the relationships of these factors with clinical variables.MethodsA total of 33 patients with SSc were enrolled and compared to 40 controls. After obtaining circular scans around the optic disc, the global and quadrant peripapillary choroidal thickness (pCT) and RNFL thickness were measured. Additionally, the peripapillary choroidal vascularity index (pCVI), which allows for a quantitative analysis of the choroidal vasculature, was determined.ResultsNo significant differences were found in pCT and RNFL thickness between patients with SSc and controls, or within SSc subtypes (diffuse cutaneous systemic sclerosis (dcSSc) compared to limited cutaneous systemic sclerosis (lcSSc)) (p &gt; 0.05). The pCVI was significantly lower in patients with SSc than in control subjects (64.25 ± 1.94 vs.65.73 ± 2.12, p &lt; 0.001).ConclusionOur results suggest that the statistically significant decrease in pCVI in patients with SSc compared to the control group is probably due to a decrease in the vascular layer, which would partially explain an increased risk of GON in patients with SSc.</description><identifier>ISSN: 2296-858X</identifier><identifier>EISSN: 2296-858X</identifier><identifier>DOI: 10.3389/fmed.2023.1273438</identifier><language>eng</language><publisher>Frontiers Media S.A</publisher><subject>choroidal vascularity index ; glaucomatous optic neuropathy ; Medicine ; peripapillary choroidal thickness ; retinal nerve fiber layer ; systemic sclerosis</subject><ispartof>Frontiers in medicine, 2023-10, Vol.10, p.1273438-1273438</ispartof><rights>Copyright © 2023 Pieklarz, Gińdzieńska-Sieśkiewicz, Zawadzka, Bagrowska, Daniluk, Sidorczuk, Kowal-Bielecka, Konopińska and Dmuchowska. 2023 Pieklarz, Gińdzieńska-Sieśkiewicz, Zawadzka, Bagrowska, Daniluk, Sidorczuk, Kowal-Bielecka, Konopińska and Dmuchowska</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c395t-e7061fdb15b2755d49271cd103c04bda69df0f50fd7dff22ed6295b1e4533b763</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10617027/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10617027/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids></links><search><creatorcontrib>Pieklarz, Barbara</creatorcontrib><creatorcontrib>Gińdzieńska-Sieśkiewicz, Ewa</creatorcontrib><creatorcontrib>Zawadzka, Izabela</creatorcontrib><creatorcontrib>Bagrowska, Magdalena</creatorcontrib><creatorcontrib>Daniluk, Joanna</creatorcontrib><creatorcontrib>Sidorczuk, Patryk</creatorcontrib><creatorcontrib>Kowal-Bielecka, Otylia</creatorcontrib><creatorcontrib>Konopińska, Joanna</creatorcontrib><creatorcontrib>Dmuchowska, Diana Anna</creatorcontrib><title>Peripapillary choroidal vascularity index and thickness in patients with systemic sclerosis</title><title>Frontiers in medicine</title><description>IntroductionPatients with systemic sclerosis (SSc) present an increased risk of developing glaucomatous optic neuropathy (GON). We investigated peripapillary choroidal parameters and peripapillary retinal nerve fiber layer (RNFL) thickness using spectral domain optical coherence tomography (SD-OCT) to determine the relationships of these factors with clinical variables.MethodsA total of 33 patients with SSc were enrolled and compared to 40 controls. After obtaining circular scans around the optic disc, the global and quadrant peripapillary choroidal thickness (pCT) and RNFL thickness were measured. Additionally, the peripapillary choroidal vascularity index (pCVI), which allows for a quantitative analysis of the choroidal vasculature, was determined.ResultsNo significant differences were found in pCT and RNFL thickness between patients with SSc and controls, or within SSc subtypes (diffuse cutaneous systemic sclerosis (dcSSc) compared to limited cutaneous systemic sclerosis (lcSSc)) (p &gt; 0.05). The pCVI was significantly lower in patients with SSc than in control subjects (64.25 ± 1.94 vs.65.73 ± 2.12, p &lt; 0.001).ConclusionOur results suggest that the statistically significant decrease in pCVI in patients with SSc compared to the control group is probably due to a decrease in the vascular layer, which would partially explain an increased risk of GON in patients with SSc.</description><subject>choroidal vascularity index</subject><subject>glaucomatous optic neuropathy</subject><subject>Medicine</subject><subject>peripapillary choroidal thickness</subject><subject>retinal nerve fiber layer</subject><subject>systemic sclerosis</subject><issn>2296-858X</issn><issn>2296-858X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNpVkUtvEzEUhS0EElXoD2DnJZsE23c89qwQqnhUqkQXICGxsPy4blwm48GelObf45AI0ZWt46vP95xDyGvONgB6eBt3GDaCCdhwoaAD_YxcCDH0ay319-f_3V-Sy1rvGWMchOw4XJAft1jSbOc0jrYcqN_mklOwI32w1e-blpYDTVPAR2qnQJdt8j8nrLVpdLZLwmmp9HdatrQe6oK75Gn1I5ZcU31FXkQ7Vrw8nyvy7eOHr1ef1zdfPl1fvb9ZexjkskbFeh6D49IJJWXoBqG4D5yBZ50Lth9CZFGyGFSIUQgMvRik49hJAKd6WJHrEzdke2_mknbNisk2mb9CLnfGliW1tYx2qhNgGQrpuojaMqciWMBgMXrwjfXuxJr3rqXqm79ixyfQpy9T2pq7_GB4M6FYi39F3pwJJf_aY13MLlWPLd8J874aobWUHdMc2ig_jfqWVy0Y__3DmTk2a47NmmOz5tws_AFcDpt0</recordid><startdate>20231016</startdate><enddate>20231016</enddate><creator>Pieklarz, Barbara</creator><creator>Gińdzieńska-Sieśkiewicz, Ewa</creator><creator>Zawadzka, Izabela</creator><creator>Bagrowska, Magdalena</creator><creator>Daniluk, Joanna</creator><creator>Sidorczuk, Patryk</creator><creator>Kowal-Bielecka, Otylia</creator><creator>Konopińska, Joanna</creator><creator>Dmuchowska, Diana Anna</creator><general>Frontiers Media S.A</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20231016</creationdate><title>Peripapillary choroidal vascularity index and thickness in patients with systemic sclerosis</title><author>Pieklarz, Barbara ; Gińdzieńska-Sieśkiewicz, Ewa ; Zawadzka, Izabela ; Bagrowska, Magdalena ; Daniluk, Joanna ; Sidorczuk, Patryk ; Kowal-Bielecka, Otylia ; Konopińska, Joanna ; Dmuchowska, Diana Anna</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c395t-e7061fdb15b2755d49271cd103c04bda69df0f50fd7dff22ed6295b1e4533b763</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>choroidal vascularity index</topic><topic>glaucomatous optic neuropathy</topic><topic>Medicine</topic><topic>peripapillary choroidal thickness</topic><topic>retinal nerve fiber layer</topic><topic>systemic sclerosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pieklarz, Barbara</creatorcontrib><creatorcontrib>Gińdzieńska-Sieśkiewicz, Ewa</creatorcontrib><creatorcontrib>Zawadzka, Izabela</creatorcontrib><creatorcontrib>Bagrowska, Magdalena</creatorcontrib><creatorcontrib>Daniluk, Joanna</creatorcontrib><creatorcontrib>Sidorczuk, Patryk</creatorcontrib><creatorcontrib>Kowal-Bielecka, Otylia</creatorcontrib><creatorcontrib>Konopińska, Joanna</creatorcontrib><creatorcontrib>Dmuchowska, Diana Anna</creatorcontrib><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Frontiers in medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pieklarz, Barbara</au><au>Gińdzieńska-Sieśkiewicz, Ewa</au><au>Zawadzka, Izabela</au><au>Bagrowska, Magdalena</au><au>Daniluk, Joanna</au><au>Sidorczuk, Patryk</au><au>Kowal-Bielecka, Otylia</au><au>Konopińska, Joanna</au><au>Dmuchowska, Diana Anna</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Peripapillary choroidal vascularity index and thickness in patients with systemic sclerosis</atitle><jtitle>Frontiers in medicine</jtitle><date>2023-10-16</date><risdate>2023</risdate><volume>10</volume><spage>1273438</spage><epage>1273438</epage><pages>1273438-1273438</pages><issn>2296-858X</issn><eissn>2296-858X</eissn><abstract>IntroductionPatients with systemic sclerosis (SSc) present an increased risk of developing glaucomatous optic neuropathy (GON). We investigated peripapillary choroidal parameters and peripapillary retinal nerve fiber layer (RNFL) thickness using spectral domain optical coherence tomography (SD-OCT) to determine the relationships of these factors with clinical variables.MethodsA total of 33 patients with SSc were enrolled and compared to 40 controls. After obtaining circular scans around the optic disc, the global and quadrant peripapillary choroidal thickness (pCT) and RNFL thickness were measured. Additionally, the peripapillary choroidal vascularity index (pCVI), which allows for a quantitative analysis of the choroidal vasculature, was determined.ResultsNo significant differences were found in pCT and RNFL thickness between patients with SSc and controls, or within SSc subtypes (diffuse cutaneous systemic sclerosis (dcSSc) compared to limited cutaneous systemic sclerosis (lcSSc)) (p &gt; 0.05). The pCVI was significantly lower in patients with SSc than in control subjects (64.25 ± 1.94 vs.65.73 ± 2.12, p &lt; 0.001).ConclusionOur results suggest that the statistically significant decrease in pCVI in patients with SSc compared to the control group is probably due to a decrease in the vascular layer, which would partially explain an increased risk of GON in patients with SSc.</abstract><pub>Frontiers Media S.A</pub><doi>10.3389/fmed.2023.1273438</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record>
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subjects choroidal vascularity index
glaucomatous optic neuropathy
Medicine
peripapillary choroidal thickness
retinal nerve fiber layer
systemic sclerosis
title Peripapillary choroidal vascularity index and thickness in patients with systemic sclerosis
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