NT-PROBNP: A Biochemical Marker of Maternal Complications in Pre-eclampsia

Introduction: Elevated serum levels of NT-proBNP (N terminal pro-Brain Natriuretic Peptide) are associated with Pre-Eclampsia (PE) and its complications. Aim: To evaluate NT-proBNP in women with PE and correlate its levels with maternal outcome. Materials and Methods: A total 90 out of which 45 wome...

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Published in:Journal of clinical and diagnostic research 2017-11, Vol.11 (11), p.QC12-QC16
Main Authors: Kumari, Supriya, Gupta, Mamta, Vardhan, Harsh, Saini, Vandana, Gupta, S.K.
Format: Article
Language:English
Subjects:
hypertensive disorders
maternal complications
n terminal pro-brain natriuretic peptide
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Summary:Introduction: Elevated serum levels of NT-proBNP (N terminal pro-Brain Natriuretic Peptide) are associated with Pre-Eclampsia (PE) and its complications. Aim: To evaluate NT-proBNP in women with PE and correlate its levels with maternal outcome. Materials and Methods: A total 90 out of which 45 women with PE (Group A) and 45 normotensive healthy pregnant women with singleton pregnancy (Group B) were enrolled. NT-proBNP was estimated at term or just before induction of labour or in early labour. These women were followed till 48 hours postpartum. Maternal outcome was recorded and analysed using statistical tests like Student t-test, Mann-whitney, ANOVA, Kruskal Wallis, Pearson and Spearman correlation. Results: Significant elevated serum levels of NT-proBNP were seen in PE women than controls (mean 439.47±431.99 and 99.40±37.89 respectively) (p-value
ISSN:2249-782X
0973-709X
DOI:10.7860/JCDR/2017/28713.10855