Albumin Urinary Excretion Is Associated with Increased Levels of Urinary Chemokines, Cytokines, and Growth Factors Levels in Humans

The aim of the present study was to study the associations between urine albumin excretion, and a large number of urinary chemokines, cytokines, and growth factors in a normal population. We selected 90 urine samples from individuals without CVD, diabetes, stroke or kidney disease belonging to the P...

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Bibliographic Details
Published in:Biomolecules (Basel, Switzerland) Switzerland), 2021-03, Vol.11 (3), p.396
Main Authors: Fellström, Bengt, Helmersson-Karlqvist, Johanna, Lind, Lars, Soveri, Inga, Thulin, Måns, Ärnlöv, Johan, Kultima, Kim, Larsson, Anders
Format: Article
Language:English
Subjects:
Albumin
Biomarkers
Body mass index
Chemokines
Creatinine
Cytokines
Diabetes
Diabetes mellitus
Epidermal growth factor receptors
Excretion
Fatty acid-binding protein
Fatty acids
Glomerular filtration rate
glomerular injury
Growth factors
Hepatocyte growth factor
Interleukin 6
Interleukin 8
Intestine
Investigations
Kidney diseases
Laboratories
Matrix metalloproteinase
Metalloproteinase
Molecular weight
Mortality
Osteoprotegerin
Proteins
Regression analysis
Thrombospondin
thrombospondin 2
Urine
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Summary:The aim of the present study was to study the associations between urine albumin excretion, and a large number of urinary chemokines, cytokines, and growth factors in a normal population. We selected 90 urine samples from individuals without CVD, diabetes, stroke or kidney disease belonging to the Prospective Investigation of the Vasculature in Uppsala Seniors Study (41 males and 49 females, all aged 75 years). Urinary cytokine levels were analyzed with two multiplex assays (proximity extension assays) and the cytokine levels were correlated with urine albumin. After adjustment for sex, body mass index (BMI), estimated glomerular filtration rate (eGFR), smoking and multiplicity testing, 11 biomarkers remained significantly associated with urine albumin: thrombospondin 2, interleukin 6, interleukin 8, hepatocyte growth factor, matrix metalloproteinase-12 (MMP-12), C-X-C motif chemokine 9, tumor necrosis factor receptor superfamily member 11B, osteoprotegerin, growth-regulated alpha protein, C-X-C motif chemokine 6, oncostatin-M (OSM) and fatty acid-binding protein, intestinal, despite large differences in molecular weights. In this study, we found associations between urinary albumin and both small and large urine proteins. Additional studies are warranted to identify cytokine patterns and potential progression markers in various renal diseases.
ISSN:2218-273X
2218-273X
DOI:10.3390/biom11030396