Improvement of heart rate variability after metabolic bariatric surgery in Korean subjects with obesity

• Published in: Journal of diabetes investigation 2024-12, Vol.15 (12), p.1773-1780
• Main Authors: Jang, Han Na, Park, Young Suk, Moon, Joon Ho, Choi, Sung Hee, Jang, Hak Chul, Oh, Tae Jung
• Format: Article
• Language: English
• Subjects: Adult; Autonomic nervous system; Bariatric Surgery; Blood pressure; Body fat; Body mass; Body mass index; Body weight loss; Cardiovascular autonomic neuropathy; Cardiovascular diseases; Cholesterol; Diabetes; Diabetes mellitus; Diabetic neuropathy; Electrocardiography; Female; Gastrointestinal surgery; Heart rate; Heart Rate - physiology; Heart rate variability; Humans; Insulin resistance; Lean body mass; Male; Metabolic bariatric surgery; Metabolism; Middle Aged; Mortality; Nervous system; Neuropathy; Obesity; Obesity - complications; Obesity - physiopathology; Obesity - surgery; Original; Orthostatic hypotension; Prospective Studies; Republic of Korea - epidemiology; Risk factors; Surgery; Treatment Outcome; Variables
• ISSN: 2040-1116; 2040-1124; 2040-1124
• DOI: 10.1111/jdi.14332

ABSTRACT Introduction Cardiovascular autonomic neuropathy (CAN) is a chronic complication of diabetes. As obesity is a major risk factor for CAN, we hypothesized that metabolic bariatric surgery (MBS) could improve CAN indices in Korean patients with obesity. Materials and Methods Patients who underwent bariatric surgery between February 2020 and June 2022 were prospectively recruited. CAN was conducted once before surgery and again after surgery, using the Ewing method and heart rate variability (HRV) analysis (standard deviation of the NN interval [SDNN], root mean square of successive RR interval difference [RMSSD], and spectral analysis). Results A total of 47 patients were included. The mean age was 39.8 ± 8.7 years, 15 (31.9%) were male, and 26 (55.3%) had diabetes. Resting HR before surgery was 81.0 ± 12.3 bpm, which decreased significantly to 68.0 ± 9.3 bpm after surgery (P