Lactic alkalosis in intensive care: a red flag?

[...]alkalosis stimulates glycolysis by increasing the activity of phosphofructokinase, which is sensitive to both pH itself and to alkalosis-induced sympathetic hyperactivation; second, alkalosis-induced left shift in the hemoglobin dissociation curve decreases oxygen tissue extraction, which may e...

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Bibliographic Details
Published in:Critical care (London, England) England), 2023-05, Vol.27 (1), p.184-184, Article 184
Main Authors: Dargent, Auguste, Wallet, Florent, Friggeri, Arnaud, Bohe, Julien, Vacheron, Charles-Hervé
Format: Article
Language:English
Subjects:
Acidosis
Acids
Alkalosis
Alkalosis - etiology
Correspondence
Critical Care
Humans
Intensive care
Intensive Care Units
Lactic Acid
Metabolism
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Summary:[...]alkalosis stimulates glycolysis by increasing the activity of phosphofructokinase, which is sensitive to both pH itself and to alkalosis-induced sympathetic hyperactivation; second, alkalosis-induced left shift in the hemoglobin dissociation curve decreases oxygen tissue extraction, which may explain the decrease in oxygen consumption observed in the seminal study by Bersin [3]. During exercise in man, experimental studies observed the same positive correlation between pH and lactate output, which was interpreted as a protective mechanism to regulate cellular acid production and protect muscle pH [4]. Hood VL, Schubert C, Keller U, Muller S. Effect of systemic pH on pHi and lactic acid generation in exhaustive forearm exercise.
ISSN:1364-8535
1466-609X
1364-8535
1366-609X
DOI:10.1186/s13054-023-04464-z