A liquid biopsy signature of circulating exosome-derived mRNAs, miRNAs and lncRNAs predict therapeutic efficacy to neoadjuvant chemotherapy in patients with advanced gastric cancer

At present, there is no validated marker to identify the subpopulation of patients with advanced gastric cancer (AGC) who might benefit from neoadjuvant chemotherapy (NACT). In view of this clinical challenge, the identification of non-invasive biomarkers for efficacy prediction of NACT in patients...

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Bibliographic Details
Published in:Molecular cancer 2022-12, Vol.21 (1), p.216-216, Article 216
Main Authors: Guo, Ting, Tang, Xiao-Huan, Gao, Xiang-Yu, Zhou, Yuan, Jin, Bo, Deng, Zi-Qian, Hu, Ying, Xing, Xiao-Fang, Li, Zi-Yu, Ji, Jia-Fu
Format: Article
Language:English
Subjects:
5-Fluorouracil
Adjuvant treatment
Advanced gastric cancer
Analysis
Biomarker panel for efficacy prediction
Biomarkers
Biopsy
Cancer
Cancer patients
Chemotherapy
Correspondence
Exosome
Gastric cancer
Genomes
Health aspects
Humans
Invasiveness
Liquid Biopsy
Medical prognosis
Medical research
Messenger RNA
MicroRNA
MicroRNAs
MicroRNAs - genetics
miRNA
Multi-omics characteristics of RNAs
Mutation
Neoadjuvant chemotherapy
Neoadjuvant Therapy
Non-coding RNA
Plasma
RNA sequencing
RNA, Long Noncoding - genetics
RNA, Messenger - genetics
Stomach cancer
Stomach Neoplasms - drug therapy
Stomach Neoplasms - genetics
Stomach Neoplasms - pathology
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Summary:At present, there is no validated marker to identify the subpopulation of patients with advanced gastric cancer (AGC) who might benefit from neoadjuvant chemotherapy (NACT). In view of this clinical challenge, the identification of non-invasive biomarkers for efficacy prediction of NACT in patients with AGC is imperative. Herein, we aimed to develop a non-invasive, liquid-biopsy-based assay by using an exosome-derived RNAs model based on multi-omics characteristics of RNAs. We firstly used a multi-omics strategy to characterize the mRNAs, microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) profiles of circulating exosome enriched fractions in responders to NACT paired with non-responders, using RNA sequencing. Finally, numerous miRNAs, mRNAs and lncRNAs were identified to be associated with the response to NACT in patients with AGC, and it was validated in an independent cohort with promising AUC values. Furthermore, we established a 6-exosome-RNA panel that could robustly identified responders from non-responders treated with fluorouracil-based neoadjuvant chemotherapy.
ISSN:1476-4598
1476-4598
DOI:10.1186/s12943-022-01684-9