Clinical and Molecular Features of Anti-CENP-B Autoantibodies

Centromeric proteins are the foundation for assembling the kinetochore, a macromolecular complex that is essential for accurate chromosome segregation during mitosis. Anti-centromere antibodies (ACAs) are polyclonal autoantibodies targeting centromeric proteins (CENP-A, CENP-B, CENP-C), predominantl...

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Bibliographic Details
Published in:Journal of Molecular Pathology 2021-12, Vol.2 (4), p.281-295
Main Authors: Prasad, Rahul M., Bellacosa, Alfonso, Yen, Tim J.
Format: Article
Language:English
Subjects:
Antibodies
Antigens
Autoantibodies
autoimmunity
Breast cancer
cancer
Cell division
CENP-B
centromere
Centromere protein A
Chromosomes
Crest syndrome
Disease
Lung cancer
Macromolecules
Medical diagnosis
Mitosis
Mutation
Patients
Proteins
RNA polymerase
Scleroderma
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Summary:Centromeric proteins are the foundation for assembling the kinetochore, a macromolecular complex that is essential for accurate chromosome segregation during mitosis. Anti-centromere antibodies (ACAs) are polyclonal autoantibodies targeting centromeric proteins (CENP-A, CENP-B, CENP-C), predominantly CENP-B, and are highly associated with rheumatologic disease (lcSSc/CREST syndrome). CENP-B autoantibodies have also been reported in cancer patients without symptoms of rheumatologic disease. The rise of oncoimmunotherapy stimulates inquiry into how and why anti-CENP-B autoantibodies are formed. In this review, we describe the clinical correlations between anti-CENP-B autoantibodies, rheumatologic disease, and cancer; the molecular features of CENP-B; possible explanations for autoantigenicity; and, finally, a possible mechanism for induction of autoantibody formation.
ISSN:2673-5261
2673-5261
DOI:10.3390/jmp2040024