Reclamation of Herb Residues Using Probiotics and Their Therapeutic Effect on Diarrhea

Residues from herbal medicine processing in pharmaceutical plants create a large amount of waste (herb residues), which consists mainly of environmental pollution and medicinal waste. In order to resolve this problem, probiotics of Bacillus (B.) subtilis, Aspergillus (A.) oryzae, and Lactobacillus (...

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Bibliographic Details
Published in:Mediators of inflammation 2017-01, Vol.2017 (2017), p.1-8
Main Authors: Tang, Xianyao, Wang, Xiaolei, Xin, Hongbo, Hai, Zhiwen, Wang, Huan, Tian, Puyuan, Zhao, Xiaoxiao, Wang, Xin, Ma, Dongwen, Chen, Tingtao, Meng, Fanjing, Shen, Liang
Format: Article
Language:English
Subjects:
Antibiotics
Antimicrobial agents
By-products
Care and treatment
Chelation
Diarrhea
Disease prevention
Enzymes
Fermentation
Food science
Health aspects
Herbal medicine
Iron
Listeria
Listeria monocytogenes
Medicinal plants
Medicine
Medicine, Botanic
Medicine, Herbal
Microorganisms
Nutrition
Pharmaceutical industry
Probiotics
Public health
Tablets
Waste products
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Summary:Residues from herbal medicine processing in pharmaceutical plants create a large amount of waste (herb residues), which consists mainly of environmental pollution and medicinal waste. In order to resolve this problem, probiotics of Bacillus (B.) subtilis, Aspergillus (A.) oryzae, and Lactobacillus (L.) plantarum M3 are selected to reuse herb residue of Jianweixiaoshi tablets (JT), and an antibiotic-associated diarrhea (AAD) mouse model was established to evaluate the therapeutic effects of the herb residue fermentation supernatant. Our results indicated that the fermentation supernatant had scavenged 77.8% of 2,2-diphenyl-1-picrylhydrazyl (DPPH), 78% of O2•−, 36.7% of •OH, 39% of Fe2+ chelation, and 716 mg/L reducing power. The inhibition zones for Salmonella (S.) typhimurium, S. enteritidis, Shigella (Sh.) flexneri, Escherichia (E.) coli, Listeria (L.) monocytogenes, Sh. dysenteriae 301, and Staphylococcus (S.) aureus were 17, 14, 19, 18, 20, 19, and 20 mm, respectively. The in vivo results indicated that the fermentation supernatant resulted in a high diarrhea inhibition rate (56%, p
ISSN:0962-9351
1466-1861
DOI:10.1155/2017/4265898