Autologous Blood Transfusion after Local Infiltration Analgesia with Ropivacaine in Total Knee and Hip Arthroplasty

Aims. To study the safety of autotransfusion following local infiltration analgesia (LIA) with ropivacaine. Background. Knowledge of blood concentrations of ropivacaine after LIA and autotransfusion is crucial. However, very limited data are available for toxicological risk assessment. Methods. Auto...

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Published in:Anesthesiology Research and Practice 2012-01, Vol.2012 (2012), p.99-104
Main Authors: Breindahl, Torben, Simonsen, Ole, Hindersson, Peter, Brødsgaard Dencker, Bjarne, Brouw Jørgensen, Mogens, Rasmussen, Sten
Format: Article
Language:English
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Summary:Aims. To study the safety of autotransfusion following local infiltration analgesia (LIA) with ropivacaine. Background. Knowledge of blood concentrations of ropivacaine after LIA and autotransfusion is crucial. However, very limited data are available for toxicological risk assessment. Methods. Autotransfusion was studied in patients after total knee arthroplasty (TKA: n=25) and total hip arthroplasty (THA: n=27) with LIA using 200 mg ropivacaine, supplemented with two postoperative bolus injections (150 mg ropivacaine). Drainage blood was reinfused within 6 h postoperatively. Results. Reinfusion caused a significant increase in the serum concentration of total ropivacaine for TKA from 0.54±0.17 (mean ± SD) to 0.79±0.20 μg/mL (P
ISSN:1687-6962
1687-6970
DOI:10.1155/2012/458795