Alexidine: a Safer and an Effective Root Canal Irrigant than Chlorhexidine

Chlorhexidine (CHX) is generally used as the final irrigating solution in root canal therapy. Recent studies have reported that, toxic precipitates containing parachloroaniline (PCA) are formed when CHX reacts with sodium hypochlorite (NaOCl). Whereas, Alexidine (ALX), a bisbiguanide disinfectant si...

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Bibliographic Details
Published in:Journal of clinical and diagnostic research 2017-07, Vol.11 (7), p.ZC18-ZC21
Main Authors: Surender, L R, Shikha, A, Swathi, A, Manaswini, C, Habeeb, Aisha, Prabha, S Shashi
Format: Article
Language:English
Subjects:
antimicrobial property
Dentistry Section
disc diffusion method
parachloroaniline
sodium hypochlorite
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Summary:Chlorhexidine (CHX) is generally used as the final irrigating solution in root canal therapy. Recent studies have reported that, toxic precipitates containing parachloroaniline (PCA) are formed when CHX reacts with sodium hypochlorite (NaOCl). Whereas, Alexidine (ALX), a bisbiguanide disinfectant similar to CHX, has proven to form no precipitates with NaOCl. To compare antimicrobial activity of different concentrations of ALX with CHX individually and when combined with NaOCl against strains. Different concentrations of ALX and CHX (0.5%, 1%, and 2%) were tested individually and when mixed with 2.5% NaOCl (1:1 ratio) using disc diffusion method against . After 24 hours incubation at 37°C, zones of inhibition were measured for each solution. The results obtained were statistically analysed using one way ANOVA and Scheffe's post-hoc tests. The p-value
ISSN:2249-782X
0973-709X
DOI:10.7860/JCDR/2017/27429.10160