Hypoxia-induced pulmonary vasoconstriction of intra-acinar arteries is impaired in NADPH oxidase 4 gene-deficient mice

We show that genetic deficiency of the reactive oxygen species generating enzyme NADPH oxidase 4 (NOX4) impairs hypoxic pulmonary vasoconstriction in small (25–40 µm) intra-acinar, but not pre-acinar, arteries in murine precision cut lung slices. These data suggest an involvement of NOX4 in ventilat...

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Bibliographic Details
Published in:Pulmonary circulation 2018-10, Vol.8 (4), p.1-4
Main Authors: Murtaza, Ghulam, Paddenberg, Renate, Pfeil, Uwe, Goldenberg, Anna, Mermer, Petra, Kummer, Wolfgang
Format: Article
Language:English
Subjects:
hypoxic pulmonary vasoconstriction
NADPH oxidase 4 (NOX4)
NOX4 knockout mice
precision‐cut lung slices
Reactive oxygen species
Research Letter
Rodents
videomorphometry
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Summary:We show that genetic deficiency of the reactive oxygen species generating enzyme NADPH oxidase 4 (NOX4) impairs hypoxic pulmonary vasoconstriction in small (25–40 µm) intra-acinar, but not pre-acinar, arteries in murine precision cut lung slices. These data suggest an involvement of NOX4 in ventilation-perfusion matching at the acinar level.
ISSN:2045-8940
2045-8932
2045-8940
DOI:10.1177/2045894018808240