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Histidine-rich glycoprotein as an excellent biomarker for sepsis and beyond

Sepsis remains a critical problem with high morbidity and mortality worldwide. One of the problems we have in critical care is the need to find a good biomarker of sepsis to determine the existence of bacterial infection and the severity of patients. This would enable us to start appropriate treatme...

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Bibliographic Details
Published in:Critical care (London, England) England), 2018-08, Vol.22 (1), p.209-209, Article 209
Main Authors: Nishibori, Masahiro, Wake, Hidenori, Morimatsu, Hiroshi
Format: Article
Language:English
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Summary:Sepsis remains a critical problem with high morbidity and mortality worldwide. One of the problems we have in critical care is the need to find a good biomarker of sepsis to determine the existence of bacterial infection and the severity of patients. This would enable us to start appropriate treatment at an earlier stage of the disease course. We propose that decreases in the plasma protein histidine-rich glycoprotein (HRG) is an excellent biomarker of sepsis compared with the current markers. Based on the novel pathophysiological roles of HRG in the cascade of events during sepsis, we also discuss the potential for supplemental therapy with purified HRG.
ISSN:1364-8535
1466-609X
1364-8535
1366-609X
DOI:10.1186/s13054-018-2127-5