Biomimetic Nanocarriers for Cancer Target Therapy

Nanotechnology offers innovative tools for the design of biomimetic nanocarriers for targeted cancer therapy. These nano-systems present several advantages such as cargo's protection and modulation of its release, inclusion of stimuli-responsive elements, and enhanced tumoral accumulation. All...

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Bibliographic Details
Published in:Bioengineering (Basel) 2020-09, Vol.7 (3), p.111
Main Authors: Guido, Clara, Maiorano, Gabriele, Cortese, Barbara, D'Amone, Stefania, Palamà, Ilaria Elena
Format: Article
Language:English
Subjects:
Biocompatibility
Bioengineering
Biomedical materials
biomimetic nanoparticles
Biomimetics
Blood platelets
Cancer
Cancer therapies
cancer therapy
Cell membranes
Chemotherapy
Clinical trials
Erythrocytes
Immune clearance
Immune system
immunotherapy
Leukocytes
Membranes
Metastasis
Nanomaterials
Nanoparticles
Nanotechnology
Platelets
Polymers
Proteins
Review
Stem cells
Therapy
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Summary:Nanotechnology offers innovative tools for the design of biomimetic nanocarriers for targeted cancer therapy. These nano-systems present several advantages such as cargo's protection and modulation of its release, inclusion of stimuli-responsive elements, and enhanced tumoral accumulation. All together, these nano-systems suffer low therapeutic efficacy in vivo because organisms can recognize and remove foreign nanomaterials. To overcome this important issue, different modifications on nanoparticle surfaces were exploited in order to reach the desired therapeutic efficacy eliciting, also, the response of immune system against cancer cells. For this reason, more recently, a new strategy involving cell membrane-covered nanoparticles for biomedical application has been attracting increasing attention. Membranes from red blood cells, platelets, leukocytes, tumor, and stem cells, have been exploited as biomimetic coatings of nanoparticles for evading clearance or stimulated immune system by maintaining in the same way their targeting capability. In this review, the use of different cell sources as coating of biomimetic nanocarriers for cancer therapy is discussed.
ISSN:2306-5354
2306-5354
DOI:10.3390/bioengineering7030111