Fibroblast Growth Factor 23 and Risk of Heart Failure Subtype: The CRIC (Chronic Renal Insufficiency Cohort) Study

Heart failure (HF) is an important cause of morbidity and mortality among individuals with chronic kidney disease (CKD). A large body of evidence from preclinical and clinical studies implicates excess levels of fibroblast growth factor 23 (FGF23) in HF pathogenesis in CKD. It remains unclear whethe...

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Published in:Kidney medicine 2023-11, Vol.5 (11), p.100723-100723, Article 100723
Main Authors: Leidner, Alexander S., Cai, Xuan, Zelnick, Leila R., Lee, Jungwha, Bansal, Nisha, Pasch, Andreas, Kansal, Mayank, Chen, Jing, Anderson, Amanda Hyre, Sondheimer, James H., Lash, James P., Townsend, Raymond R., Go, Alan S., Feldman, Harold I., Shah, Sanjiv J., Wolf, Myles, Isakova, Tamara, Mehta, Rupal C., Appel, Lawrence J., Cohen, Debbie L., Nelson, Robert G., Rahman, Mahboob, Rao, Panduranga S., Shah, Vallabh O., Unruh, Mark L.
Format: Article
Language:English
Subjects:
chronic renal insufficiency
dysfunction
Fibroblast growth factor-23
heart failure
left ventricular
Original Research
phosphorous
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Summary:Heart failure (HF) is an important cause of morbidity and mortality among individuals with chronic kidney disease (CKD). A large body of evidence from preclinical and clinical studies implicates excess levels of fibroblast growth factor 23 (FGF23) in HF pathogenesis in CKD. It remains unclear whether the relationship between elevated FGF23 levels and HF risk among individuals with CKD varies by HF subtype. Prospective cohort study. A total of 3,502 participants were selected in the Chronic Renal Insufficiency Cohort study. Baseline plasma FGF23. Incident HF by subtype and total rate of HF hospitalization. HF was categorized as HF with preserved ejection fraction (HFpEF, ejection fraction [EF] ≥ 50%), HF with reduced EF (HFrEF, EF
ISSN:2590-0595
2590-0595
DOI:10.1016/j.xkme.2023.100723