Ischemia modified albumin can act as an independent predictor of inhospital mortality in patients with acute aortic dissection

• Published in: Scientific reports 2023-01, Vol.13 (1), p.343-343, Article 343
• Main Authors: Xiang, Jun, He, Ling, Pen, Tailuan, Wei, Shuliang
• Format: Article
• Language: English
• Subjects: 692/4019; 692/499; Adult; Aged; Aged, 80 and over; Albumin; Aorta; Aortic Dissection; Biomarkers; Dissection; Female; Hospital Mortality; Humanities and Social Sciences; Humans; Ischemia; Male; Middle Aged; Mortality; multidisciplinary; Patients; Predictions; Prospective Studies; Regression analysis; Retrospective Studies; Risk Factors; Science; Science (multidisciplinary); Serum Albumin; Surgery
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-023-27659-4

Acute aortic dissection (AAD) is a serious disease characterized by high mortality. However, there are no accurate indicators to predict in-hospital mortality. The objective of this study was to identify the potential value of ischemia modified albumin (IMA) in prediction of in-hospital mortality of AAD patients. This was a single-center, prospective study involved 314 patients undergoing AAD, including 197 males and 117 females, aged 26–87 (57.14 ± 21.71) years old, 116 cases of TAAD and 198 cases of TBAD (37 cases of complicated, 114 cases of high risk, and 47 cases of uncomplicated), 228 cases were underwent surgery/intervention treatment (77 cases of TAAD,151 cases of TBAD) and 86 cases were underwent conservative therapy (39 cases of TAAD, 47 cases of TBAD). The basic data, on-admission IMA level, and the all-cause in-hospital mortality was recorded. IMA in the non-survivor group and TAAD group was found to be significantly higher than that in the survivor group and TBAD group (P