Epidemiology, clinical manifestations, and molecular typing of salmonella typhi isolated from patients with typhoid fever in Lebanon

Abstract The objective of this study was to examine the epidemiology and the clinical manifestations of typhoid fever as well as the susceptibility and strain relatedness of Salmonella typhi isolates in Lebanon from 2006 to 2007. A total of 120 patients with typhoid fever were initially identified f...

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Bibliographic Details
Published in:Journal of epidemiology and global health 2015-06, Vol.5 (2), p.159-165
Main Authors: Kanj, Souha S, Kanafani, Zeina A, Shehab, Marwa, Sidani, Nisreen, Baban, Tania, Baltajian, Kedak, Dakdouki, Ghenwa K, Zaatari, Mohamad, Araj, George F, Wakim, Rima Hanna, Dbaibo, Ghassan, Matar, Ghassan M
Format: Article
Language:English
Subjects:
Ampicillin
Antimicrobial resistance
Bone marrow
Cephalosporins
Drinking water
Enteric fever
Epidemiology
Food borne diseases
Genotypes
Internal Medicine
Middle east
Molecular typing
Quinolones
Research Article
Salmonella
Salmonella typhi
Serology
Sulfamethoxazole
Trimethoprim
Typhoid
Typhoid fever
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Summary:Abstract The objective of this study was to examine the epidemiology and the clinical manifestations of typhoid fever as well as the susceptibility and strain relatedness of Salmonella typhi isolates in Lebanon from 2006 to 2007. A total of 120 patients with typhoid fever were initially identified from various areas of the country based on positive culture results for S. typhi from blood, urine, stools, bone marrow and/or positive serology. Clinical, microbiological and molecular analysis was performed on cases with complete data available. These results indicated that drinking water was an unlikely mode of transmission of the infection. Despite increasing reports of antimicrobial resistance among S. typhi isolates, the vast majority of these isolates were susceptible to various antibiotic agents, including ampicillin, cephalosporins, quinolones, and trimethoprim/sulfamethoxazole. Molecular analysis of the isolates revealed a predominance of one single genotype with no variation in distribution across the geographical regions.
ISSN:2210-6006
2210-6014
2210-6006
DOI:10.1016/j.jegh.2014.07.003