Prognostic Effects of Delayed Administration of Appropriate Antimicrobials in Bacteraemic Adults Initially Presenting with Various Body Temperatures

To investigate the different impact of delayed administration of appropriate antimicrobial therapy (AAT) on short-term mortality of bacteraemia patients initially presenting with various body temperatures (BTs). A six-year, two-center cohort consisting of adults with community-onset bacteraemia in e...

Full description

Saved in:
Bibliographic Details
Published in:Infection and drug resistance 2022-01, Vol.15, p.3149-3160
Main Authors: Ho, Ching-Yu, Hung, Yuan-Pin, Chen, Po-Lin, Hsieh, Chih-Chia, Lee, Chung-Hsun, Lee, Ching-Chi, Ko, Wen-Chien
Format: Article
Language:English
Subjects:
Adults
Anti-infective agents
antibiotic
Antibiotics
Antimicrobial agents
Bacteremia
bloodstream infection
body temperature
community-onset
Data collection
Emergency medical care
empirical
Health aspects
Hospitals
Hypothermia
Laboratories
Microorganisms
Mortality
Original Research
Pathogens
Patients
Sepsis
Taiwan
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:To investigate the different impact of delayed administration of appropriate antimicrobial therapy (AAT) on short-term mortality of bacteraemia patients initially presenting with various body temperatures (BTs). A six-year, two-center cohort consisting of adults with community-onset bacteraemia in emergency departments (EDs) was retrospectively collected. Through the multivariable analyses, clinical impacts of delayed AAT, assessed by the time gap between the first dose of AAT and ED arrival, on 30-day mortality (primary outcomes) were respectively examined in the different groups of initial BTs (iBTs). Of the 3171 adults, despite the similarities of delayed AAT in six iBT categories, hourly AAT delay was associated with an average increase in 30-day mortality rates of 0.24% in the group of iBT
ISSN:1178-6973
1178-6973
DOI:10.2147/IDR.S357183