An Exploratory Study of Washout Rate Analysis for Thallium-201 Single-Photon Emission Computed Tomography Myocardial Perfusion Imaging Using Cadmium Zinc Telluride Detectors

The aim of this study was to assess the washout rate (WOR) for thallium-201-chloride single-photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) using cadmium zinc telluride detectors for SPECT (CZT SPECT) versus conventional Anger-type SPECT (conventional SPECT). A total o...

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Bibliographic Details
Published in:Molecular imaging 2018-01, Vol.17, p.1536012118782322-1536012118782322
Main Authors: Ishihara, Masaru, Onoguchi, Masahisa, Shibutani, Takayuki
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Brief Report
Cadmium
Cadmium - chemistry
Cadmium zinc tellurides
Chlorides
Computed tomography
Detectors
Emission analysis
Emissions
Female
Humans
Linear Models
Male
Medical imaging
Middle Aged
Myocardial Perfusion Imaging - instrumentation
Perfusion
Photon emission
Photons
Single photon emission computed tomography
Tellurium - chemistry
Thallium
Thallium isotopes
Thallium Radioisotopes - chemistry
Thallium-201
Tomography
Tomography, Emission-Computed, Single-Photon - instrumentation
Zinc - chemistry
Zinc telluride
Zinc tellurides
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Summary:The aim of this study was to assess the washout rate (WOR) for thallium-201-chloride single-photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) using cadmium zinc telluride detectors for SPECT (CZT SPECT) versus conventional Anger-type SPECT (conventional SPECT). A total of 52 Japanese patients were examined using CZT SPECT and conventional SPECT, and the global WORs were compared. Additionally, the MPI WORs were compared for patients with a normal MPI versus those in whom MPI reflected the patients’ multivessel disease (MVD) MPI. Washout rates were similar when approximated by CZT SPECT versus conventional SPECT 12.59 ± 2.26%/h vs 12.57 ± 2.27%/h (P = .997), respectively. The WOR values for CZT SPECT versus conventional SPECT were 13.42%/h (1.53%/h) vs 13.93%/h (1.24%/h) (P = .337), respectively, for 7 normal MPI patients, and 10.64 ± 2.20%/h vs 10.84 ± 2.26%/h (P = .848), respectively, for 7 MVD-MPI patients. The WOR values for normal MPI versus MVD-MPI patients for CZT SPECT were 13.42 ± 1.53%/h vs 10.64 ± 2.20%/h (P = .025), respectively. Thallium-201-chloride WOR values obtained with high-efficiency CZT SPECT, which enabled significantly reduced imaging times and use of a low-dose protocol, were similar to those obtained with conventional SPECT.
ISSN:1536-0121
1535-3508
1536-0121
DOI:10.1177/1536012118782322