Patient-derived xenograft models in cancer therapy: technologies and applications

Patient-derived xenograft (PDX) models, in which tumor tissues from patients are implanted into immunocompromised or humanized mice, have shown superiority in recapitulating the characteristics of cancer, such as the spatial structure of cancer and the intratumor heterogeneity of cancer. Moreover, P...

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Bibliographic Details
Published in:Signal transduction and targeted therapy 2023-04, Vol.8 (1), p.160-160, Article 160
Main Authors: Liu, Yihan, Wu, Wantao, Cai, Changjing, Zhang, Hao, Shen, Hong, Han, Ying
Format: Article
Language:English
Subjects:
631/67/1059
631/67/70
Animals
Cancer
Cancer Research
Cancer therapies
Cell Biology
Chemotherapy
Clinical trials
Deep learning
Drug resistance
Heterografts
Humans
Immunotherapy
Internal Medicine
Medicine
Medicine & Public Health
Mice
Neoplasms - drug therapy
Neoplasms - genetics
Oncology
Pathology
Patients
Review
Review Article
Xenografts
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Summary:Patient-derived xenograft (PDX) models, in which tumor tissues from patients are implanted into immunocompromised or humanized mice, have shown superiority in recapitulating the characteristics of cancer, such as the spatial structure of cancer and the intratumor heterogeneity of cancer. Moreover, PDX models retain the genomic features of patients across different stages, subtypes, and diversified treatment backgrounds. Optimized PDX engraftment procedures and modern technologies such as multi-omics and deep learning have enabled a more comprehensive depiction of the PDX molecular landscape and boosted the utilization of PDX models. These irreplaceable advantages make PDX models an ideal choice in cancer treatment studies, such as preclinical trials of novel drugs, validating novel drug combinations, screening drug-sensitive patients, and exploring drug resistance mechanisms. In this review, we gave an overview of the history of PDX models and the process of PDX model establishment. Subsequently, the review presents the strengths and weaknesses of PDX models and highlights the integration of novel technologies in PDX model research. Finally, we delineated the broad application of PDX models in chemotherapy, targeted therapy, immunotherapy, and other novel therapies.
ISSN:2059-3635
2095-9907
2059-3635
DOI:10.1038/s41392-023-01419-2