Detection of volatile sulfur compounds (VSCs) in exhaled breath as a potential diagnostic method for oral squamous cell carcinoma

Background Oral squamous cell carcinoma causes a significant proportion of global cancer morbidity and mortality. The aim of this study is to investigate whether the exhaled breath test can be a new, non-invasive, and effective method for diagnosing oral squamous cell carcinoma. Methods A comparativ...

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Published in:BMC oral health 2022-07, Vol.22 (1), p.1-268, Article 268
Main Authors: Kwon, Ik-Jae, Jung, Tae-Young, Son, Youjeong, Kim, Bongju, Kim, Soung-Min, Lee, Jong-Ho
Format: Article
Language:English
Subjects:
Biomarkers
Biopsy
Breast cancer
Chemotherapy
Chromatography
Comparative analysis
Diagnosis
Exhaled breath
Gas chromatography
Gases
Halitosis
Head & neck cancer
Hydrogen sulfide
Identification and classification
Lung cancer
Medical diagnosis
Medical screening
Methanethiol
Morbidity
Mouth
Mouth cancer
Oral cancer
Oral carcinoma
Oral squamous cell carcinoma
Risk factors
Squamous cell carcinoma
Sulfur
Sulfur compounds
Tongue
Variance analysis
Volatile organic compounds
Volatile sulfur compounds
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Summary:Background Oral squamous cell carcinoma causes a significant proportion of global cancer morbidity and mortality. The aim of this study is to investigate whether the exhaled breath test can be a new, non-invasive, and effective method for diagnosing oral squamous cell carcinoma. Methods A comparative analysis of exhaled breath between patients with oral squamous cell carcinoma (OSCC) and healthy controls (HC) was performed with the Twin Breasor II[TM], a simple gas chromatography system. Results Both hydrogen sulfide (H.sub.2S) and methyl mercaptan (Ch.sub.3SH) were significantly higher in the OSCC group than in the HC group. The total sulfur concentration was also higher in the OSCC group, but there was no significant difference in the ratio of Ch.sub.3SH to H.sub.2S between the two groups. Using logistic regression, we constructed a new variable with an area under the curve (AUC) of 0.740, 68.0% sensitivity, and 72.0% specificity. Conclusions Exhaled gas analysis via simple gas chromatography can potentially serve as an accessory non-invasive method for OSCC diagnosis. Keywords: Volatile sulfur compounds, Exhaled breath, Oral squamous cell carcinoma, Halitosis, Gas chromatography
ISSN:1472-6831
1472-6831
DOI:10.1186/s12903-022-02301-3