Dexmedetomidine aggravates hypotension following mesenteric traction during total gastrectomy: a randomized controlled trial

Mesenteric traction syndrome (MTS), which is characterized by arterial hypotension and tachycardia following mesenteric traction (MT), frequently occurs during abdominal surgery. Dexmedetomidine, commonly used in general anesthesia during major surgery, has a sympatholytic effect and attenuates the...

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Bibliographic Details
Published in:Annals of Saudi medicine 2020-05, Vol.40 (3), p.183-190
Main Authors: Chen, Zheng, Shao, Dong-Hua, Ma, Xiao-Dong, Mao, Zu-Min
Format: Article
Language:English
Subjects:
Dexmedetomidine - adverse effects
Female
Gastrectomy - adverse effects
Gastrectomy - methods
Heart Rate - drug effects
Humans
Hypnotics and Sedatives - adverse effects
Hypotension - etiology
Hypotension - physiopathology
Intraoperative Complications - etiology
Intraoperative Complications - physiopathology
Male
Mesentery - surgery
Middle Aged
Norepinephrine - blood
Original
Prospective Studies
Stomach Neoplasms - surgery
Syndrome
Tachycardia - etiology
Tachycardia - physiopathology
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Summary:Mesenteric traction syndrome (MTS), which is characterized by arterial hypotension and tachycardia following mesenteric traction (MT), frequently occurs during abdominal surgery. Dexmedetomidine, commonly used in general anesthesia during major surgery, has a sympatholytic effect and attenuates the compensatory response to hypotension. Assess the effect of dexmedetomidine on hypotension following mesenteric traction. Prospective, randomized, controlled clinical trial. Department of Anesthesiology, Zhenjiang First People's Hospital in China. Patients were randomly divided into three groups. Dexmedetomidine, 0.5 or 1.0 µg/kg, was intravenously administered over 15 minutes before skin incision followed by a maintenance rate of 0.5 µg/kg/h in groups D1 and D2, respectively; saline was administered in group C. The duration of hypotension, heart rate and plasma norepinephrine level in patients with MTS were recorded within 60 minutes following MT. 75 patients. The duration of hypotension in the MTS patients in group D1 and D2 was significantly longer than that in groups C (D1 vs. C,
ISSN:0256-4947
0975-4466
DOI:10.5144/0256-4947.2020.183