Neonatal haemolytic disease with co-existing Anti-D and Anti-C antibodies: an unusual experience

Neonatal haemolytic disease in the new-born remains of prime importance for paediatricians due to high perinatal morbidity and mortality rates. The Rh antigen family comprises several different antigens, out of which, D antigen incompatibility is well known for causing severe haemolytic disease in t...

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Bibliographic Details
Published in:Journal of the Pakistan Medical Association 2022-11, Vol.72 (11), p.2320
Main Authors: Durrani, Hafiza Mehreen, Zaman, Zubia, Mansoor Raza, Imran, Jamali, Munira, Saleem, Ayesha, Muzammil Ejaz, Shabana
Format: Article
Language:English
Subjects:
Antibodies
Bilirubin
Care and treatment
Diagnosis
Erythroblastosis fetalis
Genetic aspects
Health aspects
Infants (Newborn)
Measurement
Testing
Viral antibodies
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Summary:Neonatal haemolytic disease in the new-born remains of prime importance for paediatricians due to high perinatal morbidity and mortality rates. The Rh antigen family comprises several different antigens, out of which, D antigen incompatibility is well known for causing severe haemolytic disease in the foetus. Although the current literature shows anomalous cases where coexisting non-D-Rh and D-Rh antigens are the causative agents, there is very little information regarding post-natal outcomes in neonates bearing two different incompatibilities simultaneously. Herein, we discuss an unusual case of anti-D as well as anti-C antibodies (non-D-Rh) in a male neonate born to a Rh-negative mother, who developed jaundice and haemolysis in post-natal life. The neonate underwent exchange transfusion and photo therapy due to raised serum bilirubin levels, supplemented with repeated blood transfusions, intravenous immunoglobulin therapy, and immunosuppressive therapy. --Continue
ISSN:0030-9982
DOI:10.47391/JPMA.4564