Increased public health threat of avian-origin H3N2 influenza virus caused by its evolution in dogs

Influenza A viruses in animal reservoirs repeatedly cross species barriers to infect humans. Dogs are the closest companion animals to humans, but the role of dogs in the ecology of influenza viruses is unclear. H3N2 avian influenza viruses were transmitted to dogs around 2006 and have formed stable...

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Bibliographic Details
Published in:eLife 2023-04, Vol.12
Main Authors: Chen, Mingyue, Lyu, Yanli, Wu, Fan, Zhang, Ying, Li, Hongkui, Wang, Rui, Liu, Yang, Yang, Xinyu, Zhou, Liwei, Zhang, Ming, Tong, Qi, Sun, Honglei, Pu, Juan, Liu, Jinhua, Sun, Yipeng
Format: Article
Language:English
Subjects:
airborne transmissibility
Animals
canine h3n2 influenza virus
Dogs
Epidemiology and Global Health
Ferrets
Humans
Influenza A Virus, H3N2 Subtype
Influenza, Human
Microbiology and Infectious Disease
Orthomyxoviridae Infections - veterinary
PB1
Public Health
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Summary:Influenza A viruses in animal reservoirs repeatedly cross species barriers to infect humans. Dogs are the closest companion animals to humans, but the role of dogs in the ecology of influenza viruses is unclear. H3N2 avian influenza viruses were transmitted to dogs around 2006 and have formed stable lineages. The long-term epidemic of avian-origin H3N2 virus in canines offers the best models to investigate the effect of dogs on the evolution of influenza viruses. Here, we carried out a systematic and comparative identification of the biological characteristics of H3N2 canine influenza viruses (CIVs) isolated worldwide over 10 years. We found that, during adaptation in dogs, H3N2 CIVs became able to recognize the human-like SAα2,6-Gal receptor, showed gradually increased hemagglutination (HA) acid stability and replication ability in human airway epithelial cells, and acquired a 100% transmission rate via respiratory droplets in a ferret model. We also found that human populations lack immunity to H3N2 CIVs, and even preexisting immunity derived from the present human seasonal influenza viruses cannot provide protection against H3N2 CIVs. Our results showed that canines may serve as intermediates for the adaptation of avian influenza viruses to humans. Continuous surveillance coordinated with risk assessment for CIVs is necessary.
ISSN:2050-084X
2050-084X
DOI:10.7554/eLife.83470