Plasma Epstein-Barr virus microRNA BART8-3p as a potential biomarker for detection and prognostic prediction in early nasopharyngeal carcinoma

Epstein-Barr virus (EBV) encoded microRNA BART8-3p (miR-BART8-3p) was significantly associated with the metastasis in nasopharyngeal carcinoma (NPC). To explore the clinical values of plasma miR-BART8-3p in patients with early NPC. We retrospectively analyzed 126 patients with stage I and II NPC. A...

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Bibliographic Details
Published in:Scientific reports 2024-03, Vol.14 (1), p.7433-7433, Article 7433
Main Authors: Lin, Cheng, Chen, Yuebing, Lin, Xiandong, Peng, Hewei, Huang, Juan, Lin, Shaojun, Pan, Jianji, Li, Meifang, Zong, Jingfeng
Format: Article
Language:English
Subjects:
631/67/1536
631/67/1857
631/67/1858
631/67/2322
Biomarkers
Biomarkers - metabolism
Deoxyribonucleic acid
DNA
DNA, Viral - metabolism
Epstein-Barr virus
Epstein-Barr Virus Infections - pathology
Herpesvirus 4, Human - genetics
Herpesvirus 4, Human - metabolism
Humanities and Social Sciences
Humans
Medical prognosis
Metastases
Metastasis
MicroRNAs
MicroRNAs - genetics
MicroRNAs - metabolism
miRNA
multidisciplinary
Multivariate analysis
Nasopharyngeal carcinoma
Nasopharyngeal Carcinoma - diagnosis
Nasopharyngeal Carcinoma - genetics
Nasopharyngeal Carcinoma - pathology
Nasopharyngeal Neoplasms - diagnosis
Nasopharyngeal Neoplasms - genetics
Nasopharyngeal Neoplasms - pathology
Plasma
Prognosis
Retrospective Studies
Risk groups
Science
Science (multidisciplinary)
Survival
Throat cancer
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Summary:Epstein-Barr virus (EBV) encoded microRNA BART8-3p (miR-BART8-3p) was significantly associated with the metastasis in nasopharyngeal carcinoma (NPC). To explore the clinical values of plasma miR-BART8-3p in patients with early NPC. We retrospectively analyzed 126 patients with stage I and II NPC. A receiver operating characteristic curve was used to examine the diagnostic performance. Kaplan‒Meier analysis was applied to determine survival differences. Cox regression was used for univariate and multivariate analyses. Compared to healthy subjects, plasma EBV miR-BART8-3p was highly expressed in early NPC patients. The sensitivity, specificity, and area under the curve value of plasma miR-BART8-3p combined with plasma EBV DNA was up to 88.9%, 94.4%, and 0.931. Compared to patients with low expression of miR-BART8-3p, patients with high expression of miR-BART8-3p had poorer 5-year overall survival (OS) (98.9% vs. 91.1%, P = 0.025), locoregional recurrence-free survival (LRRFS) (100% vs. 83.9%, P 
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-024-58233-1