FDG-PET in suspected dementia with Lewy bodies: a case report

Dementia with Lewy bodies (DLB) is still underdiagnosed or mistaken for other types of neurodegenerative diseases. Biomarkers such as 18-Fluorodeoxyglucose Positron Emission Tomography (FDG-PET) can be helpful. A 72-year-old gentleman presented with postural hypotension, hallucination, Parkinsonism...

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Bibliographic Details
Published in:BMC geriatrics 2019-05, Vol.19 (1), p.150-150, Article 150
Main Authors: Suantio, Astrid Melani, Huang, Hian Liang, Kwok, Cecilia Sze Nga, Teo, Darren Cheng Han, Nguyen, Minh Ha
Format: Article
Language:English
Subjects:
Activities of daily living
Aged
Antipsychotics
Atrophy
Basal ganglia
Behavior disorders
Biological markers
Biomarkers
Brain
Case Report
Case reports
Case studies
Central nervous system diseases
Cognition & reasoning
Cognitive ability
Computed tomography
Dementia
Dementia disorders
Dementia with Lewy bodies
Diagnosis
Diagnostic imaging
Drug therapy
Elderly
Elderly patients
Eye movements
FDG-PET
Fludrocortisone
Fluorodeoxyglucose F18
Geriatrics
Hallucinations
Hippocampus
Humans
Hypotension
Imaging
Lewy bodies
Lewy Body Disease - diagnostic imaging
Lewy Body Disease - psychology
Magnetic resonance imaging
Male
Midodrine
Mortality
Movement disorders
Nervous system diseases
Neurodegenerative diseases
Neuroimaging
Neurology
Older people
Orthostatic hypotension
Parkinson disease
Parkinsonism
Patients
Positron emission tomography
Positron-Emission Tomography - methods
Preservation
Proteins
Psychological aspects
Rivastigmine
Sleep
Temporal Lobe - diagnostic imaging
Tomography
Type 2 diabetes
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Description
Summary:Dementia with Lewy bodies (DLB) is still underdiagnosed or mistaken for other types of neurodegenerative diseases. Biomarkers such as 18-Fluorodeoxyglucose Positron Emission Tomography (FDG-PET) can be helpful. A 72-year-old gentleman presented with postural hypotension, hallucination, Parkinsonism and recurrent falls. He also had rapidly progressing cognitive impairment. CT and MRI brain showed atrophy of the frontal lobes with preservation of the hippocampi. FDG-PET was suggestive of DLB. He was subsequently treated with Rivastigmine, with significant improvement of his symptoms. This case highlights the challenges in diagnosis of an elderly patient with DLB, the use of neuro-imaging as a diagnostic biomarker, the avoidance of the use of antipsychotic and the response to pharmacological treatment with Rivastigmine after a probable diagnosis of DLB.
ISSN:1471-2318
1471-2318
DOI:10.1186/s12877-019-1166-3