Smoking related attention alteration in chronic obstructive pulmonary disease-smoking comorbidity

• Published in: BMC pulmonary medicine 2022-05, Vol.22 (1), p.182-182, Article 182
• Main Authors: Zeng, Feiyan, Hong, Wei, Zha, Rujing, Li, Ying, Jin, Chen, Liu, Ying, Liu, Hao, Liu, Mengqiu, Liu, Mei, Xu, Fei, Hu, Daiju, Song, Hongwen, Wu, Haiyan, Yu, Yongqiang, Zhang, Xiaochu
• Format: Article
• Language: English
• Subjects: Alzheimer's disease; Attention ability; Binding sites; Brain; Chronic obstructive pulmonary disease; Chronic obstructive pulmonary disease (COPD); Cigarettes; Cognition disorders; Cognitive ability; Comorbidity; Complications and side effects; Demographics; Executive function; Functional magnetic resonance imaging; Functional magnetic resonance imaging (fMRI); Health aspects; Hospitals; Lung diseases; Lung diseases, Obstructive; Magnetic resonance imaging; Memory; Mortality; Nicotine; Obstructive lung disease; Patients; Psychological aspects; Pulmonology; Respiratory diseases; Risk factors; Smokers; Smoking
• ISSN: 1471-2466; 1471-2466
• DOI: 10.1186/s12890-022-01964-6

Chronic obstructive pulmonary disease (COPD) is a respiratory disease that causes a wide range of cognitive impairments. Although COPD-Smoking comorbidity is common, the relationship between smoking and cognitive function in COPD-Smoking comorbidity remains unclear. This study aimed to investigate the effect of smoking on cognitive function like attention in COPD-Smoking patients. In this study, we used the Montreal Cognitive Assessment (MoCA) scale and resting-state functional magnetic resonance imaging (fMRI) to explore the effect of smoking on attention in patients with COPD. Behavioral analysis revealed that among patients with COPD the smokers had a shorter course of COPD and showed a worse attention performance than the non-smokers. Resting-state fMRI analysis revealed that among patients with COPD smokers showed lower regional homogeneity (ReHo) value of the fusiform gyrus than non-smokers. Importantly, the ReHo of the fusiform gyrus is positively associated with attention and mediates the effect of smoking on attention in COPD. In summary, our study provides behavioral and neurobiological evidence supporting the positive effect of smoking on attention in COPD. This may be helpful for understanding and treating COPD and even other diseases comorbid with smoking.