Role of naringin in the treatment of atherosclerosis

Atherosclerosis (AS) is a major pathological basis of coronary heart disease. However, the currently available medications are unable to effectively reduce the incidence of cardiovascular events in the majority of patients with AS. Therefore, naringin has been attracting considerable attention owing...

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Bibliographic Details
Published in:Frontiers in pharmacology 2024-09, Vol.15, p.1451445
Main Authors: Lu, Yan, Li, De-Hong, Xu, Ji-Mei, Zhou, Sheng
Format: Article
Language:English
Subjects:
antioxidant
atherosclerosis
endothelial cell
inflammation
naringin
vascular smooth muscle cell
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Summary:Atherosclerosis (AS) is a major pathological basis of coronary heart disease. However, the currently available medications are unable to effectively reduce the incidence of cardiovascular events in the majority of patients with AS. Therefore, naringin has been attracting considerable attention owing to its anti-AS effects. Naringin can inhibit the growth, proliferation, invasion, and migration of vascular smooth muscle cells, ameliorate endothelial cell inflammation and apoptosis, lower blood pressure, halt the cell cycle at the G1 phase, and impede growth via its antioxidant and free radical scavenging effects. These activities suggest the potential anti-AS effects of naringin. In this review article, we comprehensively summarized the latest findings on the anti-AS effects of naringin and their underlying mechanisms, providing a crucial reference for future research on the anti-AS potential of this agent.
ISSN:1663-9812
1663-9812
DOI:10.3389/fphar.2024.1451445