Developmental Pathways Direct Pancreatic Cancer Initiation from Its Cellular Origin

Pancreatic ductal adenocarcinoma (PDA) is characterized by an extremely poor prognosis, since it is usually diagnosed at advanced stages. In order to employ tools for early detection, a better understanding of the early stages of PDA development from its main precursors, pancreatic intraepithelial n...

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Bibliographic Details
Published in:Stem cells international 2016-01, Vol.2016 (2016), p.1-8
Main Authors: Hartmann, Daniel, Kleger, Alexander, Blume, Karin, Reichert, Maximilian, von Figura, Guido
Format: Article
Language:English
Subjects:
Cell differentiation
Disease
Embryonic development
Enzymes
Harbors
Medical research
Pancreatic cancer
Population
Review
Rodents
Studies
Transcription factors
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Summary:Pancreatic ductal adenocarcinoma (PDA) is characterized by an extremely poor prognosis, since it is usually diagnosed at advanced stages. In order to employ tools for early detection, a better understanding of the early stages of PDA development from its main precursors, pancreatic intraepithelial neoplasia (PanIN), and intraductal papillary mucinous neoplasm (IPMN) is needed. Recent studies on murine PDA models have identified a different exocrine origin for PanINs and IPMNs. In both processes, developmental pathways direct the initiation of PDA precursors from their cellular ancestors. In this review, the current understanding of early PDA development is summarized.
ISSN:1687-966X
1687-9678
1687-9678
DOI:10.1155/2016/9298535