Assessment of Diabetic Cardiomyopathy by Cardiovascular Magnetic Resonance T1 Mapping: Correlation with Left-Ventricular Diastolic Dysfunction and Diabetic Duration

Purpose. To quantify extracellular matrix expansion with the cardiovascular magnetic resonance (CMR) T1 mapping technique and the derived extracellular volume fraction (ECV) in diabetic cardiomyopathy (DbCM) patients and to detect the relationship among ECV, duration of diabetes, and diastolic funct...

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Bibliographic Details
Published in:Journal of diabetes research 2017-01, Vol.2017 (2017), p.1-8
Main Authors: Wang, Jian, Liang, Ziwen, Zhang, Tianjing, Lei, Xiaotian, Chen, Liu, Leng, Weiling, Zhang, Xiaochun, Shang, Yongning, Greiser, Andreas
Format: Article
Language:English
Subjects:
Adult
Aged
Biochemistry
Blood pressure
Cardiomyopathy
Cardiovascular disease
Case-Control Studies
Cholesterol
Creatinine
Dehydrogenases
Diabetes
Diabetic Cardiomyopathies - diagnostic imaging
Diabetic Cardiomyopathies - pathology
Diabetic Cardiomyopathies - physiopathology
Diastole
Early Diagnosis
Echocardiography, Doppler
Extracellular Matrix - pathology
Female
Hemoglobin
Humans
Hypertension
Lipoproteins
Magnetic Resonance Imaging
Male
Middle Aged
Myocardium - pathology
Peptides
Predictive Value of Tests
Prospective Studies
Statistical analysis
Time Factors
Triglycerides
Ventricular Dysfunction, Left - diagnostic imaging
Ventricular Dysfunction, Left - pathology
Ventricular Dysfunction, Left - physiopathology
Ventricular Function, Left
Ventricular Remodeling
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Summary:Purpose. To quantify extracellular matrix expansion with the cardiovascular magnetic resonance (CMR) T1 mapping technique and the derived extracellular volume fraction (ECV) in diabetic cardiomyopathy (DbCM) patients and to detect the relationship among ECV, duration of diabetes, and diastolic function. Materials. Thirty-eight patients with diabetic cardiomyopathy (20 males, age 54.6 ± 8.6 years) and thirty-two matched normal controls (15 males, age 51.4 ± 13.6 years) were prospectively enrolled. All of them were scanned by T1 mapping to obtain the native and postcontrast T1 values of myocardium and blood, and ECV was calculated accordingly. All patients also underwent transthoracic echocardiographic tissue Doppler imaging to assess left-ventricular diastolic function. Results. There was a significant difference in ECV between the two groups (DbCMs 30.4 ± 2.9% versus controls 27.1 ± 2.4%, P
ISSN:2314-6745
2314-6753
DOI:10.1155/2017/9584278