Assessment of Diabetic Cardiomyopathy by Cardiovascular Magnetic Resonance T1 Mapping: Correlation with Left-Ventricular Diastolic Dysfunction and Diabetic Duration

Purpose. To quantify extracellular matrix expansion with the cardiovascular magnetic resonance (CMR) T1 mapping technique and the derived extracellular volume fraction (ECV) in diabetic cardiomyopathy (DbCM) patients and to detect the relationship among ECV, duration of diabetes, and diastolic funct...

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Published in:Journal of diabetes research 2017-01, Vol.2017 (2017), p.1-8
Main Authors: Wang, Jian, Liang, Ziwen, Zhang, Tianjing, Lei, Xiaotian, Chen, Liu, Leng, Weiling, Zhang, Xiaochun, Shang, Yongning, Greiser, Andreas
Format: Article
Language:English
Subjects:
Adult
Aged
Biochemistry
Blood pressure
Cardiomyopathy
Cardiovascular disease
Case-Control Studies
Cholesterol
Creatinine
Dehydrogenases
Diabetes
Diabetic Cardiomyopathies - diagnostic imaging
Diabetic Cardiomyopathies - pathology
Diabetic Cardiomyopathies - physiopathology
Diastole
Early Diagnosis
Echocardiography, Doppler
Extracellular Matrix - pathology
Female
Hemoglobin
Humans
Hypertension
Lipoproteins
Magnetic Resonance Imaging
Male
Middle Aged
Myocardium - pathology
Peptides
Predictive Value of Tests
Prospective Studies
Statistical analysis
Time Factors
Triglycerides
Ventricular Dysfunction, Left - diagnostic imaging
Ventricular Dysfunction, Left - pathology
Ventricular Dysfunction, Left - physiopathology
Ventricular Function, Left
Ventricular Remodeling
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cited_by cdi_FETCH-LOGICAL-c635t-8133d255aa8f5dc74243790b879e5470b4152f35b02e2301c7ce943a243f3aa43
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container_end_page 8
container_issue 2017
container_start_page 1
container_title Journal of diabetes research
container_volume 2017
creator Wang, Jian
Liang, Ziwen
Zhang, Tianjing
Lei, Xiaotian
Chen, Liu
Leng, Weiling
Zhang, Xiaochun
Shang, Yongning
Greiser, Andreas
description Purpose. To quantify extracellular matrix expansion with the cardiovascular magnetic resonance (CMR) T1 mapping technique and the derived extracellular volume fraction (ECV) in diabetic cardiomyopathy (DbCM) patients and to detect the relationship among ECV, duration of diabetes, and diastolic function. Materials. Thirty-eight patients with diabetic cardiomyopathy (20 males, age 54.6 ± 8.6 years) and thirty-two matched normal controls (15 males, age 51.4 ± 13.6 years) were prospectively enrolled. All of them were scanned by T1 mapping to obtain the native and postcontrast T1 values of myocardium and blood, and ECV was calculated accordingly. All patients also underwent transthoracic echocardiographic tissue Doppler imaging to assess left-ventricular diastolic function. Results. There was a significant difference in ECV between the two groups (DbCMs 30.4 ± 2.9% versus controls 27.1 ± 2.4%, P
doi_str_mv 10.1155/2017/9584278
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To quantify extracellular matrix expansion with the cardiovascular magnetic resonance (CMR) T1 mapping technique and the derived extracellular volume fraction (ECV) in diabetic cardiomyopathy (DbCM) patients and to detect the relationship among ECV, duration of diabetes, and diastolic function. Materials. Thirty-eight patients with diabetic cardiomyopathy (20 males, age 54.6 ± 8.6 years) and thirty-two matched normal controls (15 males, age 51.4 ± 13.6 years) were prospectively enrolled. All of them were scanned by T1 mapping to obtain the native and postcontrast T1 values of myocardium and blood, and ECV was calculated accordingly. All patients also underwent transthoracic echocardiographic tissue Doppler imaging to assess left-ventricular diastolic function. Results. There was a significant difference in ECV between the two groups (DbCMs 30.4 ± 2.9% versus controls 27.1 ± 2.4%, P&lt;0.001). The duration of diabetes was positively and strongly associated with ECV (R=0.539, P=0.0005). There was also a significant difference in ECV (P≤0.001) among four groups (A, controls; B, DbCM patients with duration of diabetes &lt;5 years; C, 5–10 years; and D, &gt;10 years). ECV was negatively associated with LV E’/A’ (R=−0.403, P=0.012). Conclusion. CMR T1 mapping can reflect myocardial extracellular matrix expansion in DbCM and can be a powerful technique for the early diagnosis of DbCM.</description><identifier>ISSN: 2314-6745</identifier><identifier>EISSN: 2314-6753</identifier><identifier>DOI: 10.1155/2017/9584278</identifier><identifier>PMID: 28791311</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Adult ; Aged ; Biochemistry ; Blood pressure ; Cardiomyopathy ; Cardiovascular disease ; Case-Control Studies ; Cholesterol ; Creatinine ; Dehydrogenases ; Diabetes ; Diabetic Cardiomyopathies - diagnostic imaging ; Diabetic Cardiomyopathies - pathology ; Diabetic Cardiomyopathies - physiopathology ; Diastole ; Early Diagnosis ; Echocardiography, Doppler ; Extracellular Matrix - pathology ; Female ; Hemoglobin ; Humans ; Hypertension ; Lipoproteins ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Myocardium - pathology ; Peptides ; Predictive Value of Tests ; Prospective Studies ; Statistical analysis ; Time Factors ; Triglycerides ; Ventricular Dysfunction, Left - diagnostic imaging ; Ventricular Dysfunction, Left - pathology ; Ventricular Dysfunction, Left - physiopathology ; Ventricular Function, Left ; Ventricular Remodeling</subject><ispartof>Journal of diabetes research, 2017-01, Vol.2017 (2017), p.1-8</ispartof><rights>Copyright © 2017 Yongning Shang et al.</rights><rights>Copyright © 2017 Yongning Shang et al. 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To quantify extracellular matrix expansion with the cardiovascular magnetic resonance (CMR) T1 mapping technique and the derived extracellular volume fraction (ECV) in diabetic cardiomyopathy (DbCM) patients and to detect the relationship among ECV, duration of diabetes, and diastolic function. Materials. Thirty-eight patients with diabetic cardiomyopathy (20 males, age 54.6 ± 8.6 years) and thirty-two matched normal controls (15 males, age 51.4 ± 13.6 years) were prospectively enrolled. All of them were scanned by T1 mapping to obtain the native and postcontrast T1 values of myocardium and blood, and ECV was calculated accordingly. All patients also underwent transthoracic echocardiographic tissue Doppler imaging to assess left-ventricular diastolic function. Results. There was a significant difference in ECV between the two groups (DbCMs 30.4 ± 2.9% versus controls 27.1 ± 2.4%, P&lt;0.001). The duration of diabetes was positively and strongly associated with ECV (R=0.539, P=0.0005). There was also a significant difference in ECV (P≤0.001) among four groups (A, controls; B, DbCM patients with duration of diabetes &lt;5 years; C, 5–10 years; and D, &gt;10 years). ECV was negatively associated with LV E’/A’ (R=−0.403, P=0.012). Conclusion. 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To quantify extracellular matrix expansion with the cardiovascular magnetic resonance (CMR) T1 mapping technique and the derived extracellular volume fraction (ECV) in diabetic cardiomyopathy (DbCM) patients and to detect the relationship among ECV, duration of diabetes, and diastolic function. Materials. Thirty-eight patients with diabetic cardiomyopathy (20 males, age 54.6 ± 8.6 years) and thirty-two matched normal controls (15 males, age 51.4 ± 13.6 years) were prospectively enrolled. All of them were scanned by T1 mapping to obtain the native and postcontrast T1 values of myocardium and blood, and ECV was calculated accordingly. All patients also underwent transthoracic echocardiographic tissue Doppler imaging to assess left-ventricular diastolic function. Results. There was a significant difference in ECV between the two groups (DbCMs 30.4 ± 2.9% versus controls 27.1 ± 2.4%, P&lt;0.001). The duration of diabetes was positively and strongly associated with ECV (R=0.539, P=0.0005). There was also a significant difference in ECV (P≤0.001) among four groups (A, controls; B, DbCM patients with duration of diabetes &lt;5 years; C, 5–10 years; and D, &gt;10 years). ECV was negatively associated with LV E’/A’ (R=−0.403, P=0.012). Conclusion. CMR T1 mapping can reflect myocardial extracellular matrix expansion in DbCM and can be a powerful technique for the early diagnosis of DbCM.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>28791311</pmid><doi>10.1155/2017/9584278</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0001-9109-7853</orcidid><orcidid>https://orcid.org/0000-0001-6909-2538</orcidid><orcidid>https://orcid.org/0000-0003-1210-0837</orcidid><orcidid>https://orcid.org/0000-0001-9375-9726</orcidid><orcidid>https://orcid.org/0000-0001-5741-0607</orcidid><orcidid>https://orcid.org/0000-0003-0966-2804</orcidid><orcidid>https://orcid.org/0000-0003-4244-3865</orcidid><oa>free_for_read</oa></addata></record>
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source Wiley-Blackwell Open Access Collection; Publicly Available Content (ProQuest); PubMed Central
subjects Adult
Aged
Biochemistry
Blood pressure
Cardiomyopathy
Cardiovascular disease
Case-Control Studies
Cholesterol
Creatinine
Dehydrogenases
Diabetes
Diabetic Cardiomyopathies - diagnostic imaging
Diabetic Cardiomyopathies - pathology
Diabetic Cardiomyopathies - physiopathology
Diastole
Early Diagnosis
Echocardiography, Doppler
Extracellular Matrix - pathology
Female
Hemoglobin
Humans
Hypertension
Lipoproteins
Magnetic Resonance Imaging
Male
Middle Aged
Myocardium - pathology
Peptides
Predictive Value of Tests
Prospective Studies
Statistical analysis
Time Factors
Triglycerides
Ventricular Dysfunction, Left - diagnostic imaging
Ventricular Dysfunction, Left - pathology
Ventricular Dysfunction, Left - physiopathology
Ventricular Function, Left
Ventricular Remodeling
title Assessment of Diabetic Cardiomyopathy by Cardiovascular Magnetic Resonance T1 Mapping: Correlation with Left-Ventricular Diastolic Dysfunction and Diabetic Duration
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