Analgesic and Antioxidant Activities of 4-Phenyl-1,5-benzodiazepin-2-one and Its Long Carbon Chains Derivatives

• Published in: Journal of chemistry 2019-01, Vol.2019 (2019), p.1-7
• Main Authors: Zellou, Amina, Alaoui, Katim, Chemlal, Laila, El Jemli, Meryem, El Ouasif, Latifa, El Ghoul, Mostafa, Achour, Redouane, Nguema Ongone, Terence, Cherrah, Y.
• Format: Article
• Language: English
• Subjects: Acetic acid; Acids; Analgesics; Antioxidants; Aqueous solutions; Carbon; Chains; Chemistry; Derivatives; Drug dosages; HIV; Human immunodeficiency virus; Laboratory animals; Nervous system; Oxidation; Pain; Pharmacology; Polarity; Pretreatment; Rodents; Scavenging; Surfactants
• ISSN: 2090-9063; 2090-9071
• DOI: 10.1155/2019/9043570

The aim of this work is to deepen the pharmacological effect of 4-phenyl-1,5-benzodiazepin-2-one derivatives which have a similar structure to nonionic surfactants: 4-phenyl-1,5-benzodiazepin-2-one is the hydrophilic head, and the carbon chain is hydrophobic tail. The antinociceptive activity of 4-phenyl-1,5-benzodiazepin-2-one derivatives was determined using acetic acid-induced writhing and tail immersion tests. In addition, the in vitro antioxidant activities of the tested derivatives were determined by using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging method and ferric reducing power assay. A single oral administration of these compounds at the doses of 50 and 100 mg/kg significantly reduced the number of abdominal writhes induced by acetic acid injection. Acute pretreatment with 4-phenyl-1,5-benzodiazepin-2-one derivatives at the dose of 100 mg/kg caused a significant increase in the tail withdrawal latency in the tail immersion test. Additionally, a significant scavenging activity in DPPH and reducing power was observed in testing antioxidant assays. Finally, we carried out a study of the antioxidant activity of these derivatives. The results of this study reveal that these compounds have a low antioxidant activity compared to the BHT. It decreases with the polarity of the molecule. The present study suggests that 4-phenyl-1,5-benzodiazepin-2-one derivatives possess potent antinociceptive and antioxidant effects, which suggest that the tested compounds may be useful in the treatment of pain and oxidation disorders.