Blood pressure predictors of stroke in rural Chinese dwellers with hypertension: a large-scale prospective cohort study

• Published in: BMC cardiovascular disorders 2019-08, Vol.19 (1), p.206-206, Article 206
• Main Authors: Zheng, Jia, Sun, Zhaoqing, Guo, Xiaofan, Xie, Yanxia, Sun, Yingxian, Zheng, Liqiang
• Format: Article
• Language: English
• Subjects: Adult; Arterial Pressure; Blood Pressure; Brain Ischemia - diagnosis; Brain Ischemia - epidemiology; Brain Ischemia - physiopathology; China - epidemiology; Cohort analysis; Complications and side effects; Female; Health risk assessment; Hemorrhage; Humans; Hypertension; Hypertension - diagnosis; Hypertension - epidemiology; Hypertension - physiopathology; Incidence; Intracranial Hemorrhages - diagnosis; Intracranial Hemorrhages - epidemiology; Intracranial Hemorrhages - physiopathology; Ischemia; Male; Medical research; Middle Aged; Patient outcomes; Prognosis; Prospective Studies; Risk Assessment; Risk Factors; Rural Health; Stroke; Stroke - diagnosis; Stroke - epidemiology; Stroke - physiopathology; Time Factors
• ISSN: 1471-2261; 1471-2261
• DOI: 10.1186/s12872-019-1186-0

Little was known about the different predictive power of blood pressure (BP) parameters (SBP, systolic BP; mean arterial pressure, MAP; pulse pressure, PP; and diastolic BP, DBP) and stroke incidence. This study's aim was to compare power of BP parameters predict stroke events among rural dwelling Chinese individuals with hypertension. A total of 5097 hypertension patients (56.2% women; mean age, 56.3 ± 11.2 years) were included in the prospective cohort study with a median follow-up of 8.4 years. Until the end of the last follow-up, there were 501 onset strokes (310 ischemic, 186 hemorrhagic, and 5 unclassified strokes) among the 5097 participants. The results showed that hazard ratio (HR) (95% confidence interval, 95% CI) with an increment of 5 mmHg were 1.095 (1.070-1.121) for PP, 1.173 (1.139-1.208) for MAP, 1.109(1.089-1.130) for SBP, 1.143(1.104-1.185) for DBP. The SBP indicated the largest β coefficient in the Cox proportional hazard model for all stroke except PP or MAP, and the SBP revealed slightly higher value than MAP (β  = 0.435, β  = 0.430, P = 0.756). Both PP and MAP were predictive factors for stroke. The MAP showed a stronger ability to predict stroke events than PP, and slightly inferior to SBP for hypertension patients.