Dietary Supplementation with Silicon-Enriched Spirulina Improves Arterial Remodeling and Function in Hypertensive Rats

Vascular aging is characterized by increase in arterial stiffness and remodeling of the arterial wall with a loss of elastic properties. Silicon is an essential trace element highly present in arteries. It is involved in the constitution and stabilization of elastin fibers. The nutritional supply an...

Full description

Saved in:
Bibliographic Details
Published in:Nutrients 2019-10, Vol.11 (11), p.2574
Main Authors: Arthur-Ataam, Joanna, Bideaux, Patrice, Charrabi, Azzouz, Sicard, Pierre, Fromy, Bérengère, Liu, Kiaoling, Eddahibi, Saadia, Pasqualin, Côme, Jouy, Nicolas, Richard, Sylvain, Virsolvy, Anne
Format: Article
Language:English
Subjects:
Aging
Aorta
arterial structure
Atherosclerosis
Bioavailability
Blood pressure
Cardiology and cardiovascular system
Contractility
Coronary vessels
Depolarization
Dietary supplements
Elastin
Food
Food and Nutrition
Food sources
Human health and pathology
Hypertension
Laboratory animals
Life Sciences
Nutrient deficiency
Nutrients
Nutritional status
Potassium chloride
Silicon
spirulina
Structure-function relationships
Trace elements
vascular function
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Vascular aging is characterized by increase in arterial stiffness and remodeling of the arterial wall with a loss of elastic properties. Silicon is an essential trace element highly present in arteries. It is involved in the constitution and stabilization of elastin fibers. The nutritional supply and bioavailability of silicon are often inadequate. Spirulina (Sp), micro algae have recognized nutritional properties and are able to incorporate minerals in a bioavailable form. We evaluated the effects of nutritional supplementation with silicon-enriched spirulina (SpSi) on arterial system structure and function in hypertension. Experiments were performed on hypertensive (SHR) and normotensive Wistar-Kyoto (WKY) rats supplemented with SpSi or Sp over a period of three months. Arterial pressure, vascular function and morphometric parameters of thoracic aorta were analyzed. SpSi supplementation lowered arterial pressure in SHR and minimized morphometric alterations induced by hypertension. Aortic wall thickness and elastic fibers fragmentation were partially reversed. Collagen and elastin levels were increased in association with extracellular matrix degradation decrease. Vascular reactivity was improved with better contractile and vasorelaxant responses to various agonists. No changes were observed in SHR supplemented with Sp. The beneficial effects of SpSi supplementation evidenced here, may be attributable to Si enrichment and offer interesting opportunities to prevent cardiovascular risks.
ISSN:2072-6643
2072-6643
DOI:10.3390/nu11112574