Stem Cell Therapy for Diabetic Foot Ulcers: Theory and Practice

Diabetic foot ulcers are associated with increases in limb amputation, morbidity, and mortality. Recently, a stem cell application is emerging as promising adjuvant therapy. We presented available remedies by conducting a literature review on the application, safety, and efficacy of stem cell therap...

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Bibliographic Details
Published in:Journal of diabetes research 2022-12, Vol.2022, p.6028743-12
Main Authors: Nalisa, David Lubasi, Moneruzzaman, Md, Changwe, Geoffrey J., Mobet, Youchaou, Li, Li Ping, Ma, Yu Jin, Jiang, Hong Wei
Format: Article
Language:English
Subjects:
Aged
Amputation
Amputation, Surgical
Debridement
Diabetes
Diabetes Mellitus
Diabetic Foot - complications
Diabetic Foot - therapy
Female
Foot diseases
Humans
Infections
Keywords
Leg ulcers
Male
Metabolism
Middle Aged
Morbidity
Mortality
Physiology
Prevention
Review
Stem Cell Transplantation
Stem cells
Wound Healing
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Summary:Diabetic foot ulcers are associated with increases in limb amputation, morbidity, and mortality. Recently, a stem cell application is emerging as promising adjuvant therapy. We presented available remedies by conducting a literature review on the application, safety, and efficacy of stem cell therapy. Relevant literature, including randomized control trials and article journals, was obtained from reputable search engines (PubMed, Scopus, and Web of Science). We analyzed five credible cohorts, with variable sources of stem cells, in a total of 216 participants, 151 males and 65 females, age (mean±SD) of 64.5±9.6 years. With an average success of 86.41% in all Wagner-II lesions, mesenchymal SCA (stem cell application) is safe and effective, hence can significantly prevent limb amputation.
ISSN:2314-6745
2314-6753
DOI:10.1155/2022/6028743