Triterpenoids from Euphorbia maculata and Their Anti-Inflammatory Effects

• Published in: Molecules (Basel, Switzerland) Switzerland), 2018-08, Vol.23 (9), p.2112
• Main Authors: Sun, Yi, Gao, Liang-Liang, Tang, Meng-Yue, Feng, Bao-Min, Pei, Yue-Hu, Yasukawa, Ken
• Format: Article
• Language: English
• Subjects: Animals; anti-inflammatory activity; Anti-Inflammatory Agents - chemistry; Anti-Inflammatory Agents - pharmacology; Disease Models, Animal; Edema - drug therapy; Edema - pathology; Euphorbia; Euphorbia - chemistry; Euphorbia maculata; Female; Herbal medicine; Inflammation; Magnetic Resonance Spectroscopy; Medicinal plants; Mice; Molecular Structure; natural products; Organic chemistry; Pharmacy; Plant Extracts - chemistry; Plant Extracts - pharmacology; Triterpenes; Triterpenes - chemistry; Triterpenoids
• ISSN: 1420-3049; 1420-3049
• DOI: 10.3390/molecules23092112

is a medicinal plant of the Euphorbiaceae family, which can produce anti-inflammatory and cancer chemopreventive agents of triterpenoids. The present study reports on the bioactive triterpenoids of this plant. Two new lanostane-type triterpenoids, named (3 ,4 ,7 ,9 )-4-methyl-3,7-dihydroxy-7(8→9) -lanost-24(28)-en-8-one ( ) and 24-hydroperoxylanost-7,25-dien-3β-ol ( ), together with 15 known triterpene derivatives, were isolated from . The structures of the new compounds were determined on the basis of extensive spectroscopic data (UV, MS, ¹H and C-NMR, and 2D NMR) analysis. All tetracyclic triterpenoids ( ⁻ ) were evaluated for their anti-inflammatory effects in the test of TPA-induced inflammation (1 μg/ear) in mice. The triterpenes exhibited significant anti-inflammatory activities.