Comparative Ungual Drug Uptake Studies: Equine Hoof Membrane vs. Human Nail Plate

Human nail diseases, mostly caused by fungal infections, are common and difficult to treat. The development and testing of new drugs and drug delivery systems for the treatment of nail diseases is often limited by the lack of human nail material for permeation studies. Animal material is frequently...

Full description

Saved in:
Bibliographic Details
Published in:Pharmaceutics 2022-11, Vol.14 (12), p.2552
Main Authors: Dobler, Dorota, Gerber, Mona, Schmidts, Thomas M, Runkel, Frank, Schlupp, Peggy
Format: Article
Language:English
Subjects:
Caffeine
Drug delivery systems
Drug therapy
Drugs
Hoofs
human nail plate
Hydration
Keratin
Membranes
Nail diseases
Nails (Anatomy)
Permeability
Physiological aspects
sorbic acid
Testing
Testosterone
ungual penetration
ungual permeation
Vehicles
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Human nail diseases, mostly caused by fungal infections, are common and difficult to treat. The development and testing of new drugs and drug delivery systems for the treatment of nail diseases is often limited by the lack of human nail material for permeation studies. Animal material is frequently used, but there are only few comparative data on the human nail plate, and there is neither a standardized test design nor a nail bed analogue to study drug uptake into the nail. In this study, a new permeation device was developed for permeation studies, and the permeation behavior of three model substances on the human nail plate and a model membrane from the horse hoof was investigated. A linear correlation was found between drug uptake by the human nail plate and the uptake by the equine hoof. The developed and established permeation device is suitable for investigations of ungual drug transport and enables the use of different membrane diameters and the use of a gel-based nail bed analog. The hydrogel-based acceptor medium used ensures adequate stabilization and hydration of the nail membrane.
ISSN:1999-4923
1999-4923
DOI:10.3390/pharmaceutics14122552