Transplantation Tolerance Induction: Cell Therapies and Their Mechanisms

Cell-based therapies have been studied extensively in the context of transplantation tolerance induction. The most successful protocols have relied on transfusion of bone marrow prior to the transplantation of a renal allograft. However, it is not clear that stem cells found in bone marrow are requi...

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Bibliographic Details
Published in:Frontiers in immunology 2016-03, Vol.7, p.87-87
Main Authors: Scalea, Joseph R, Tomita, Yusuke, Lindholm, Christopher R, Burlingham, William
Format: Article
Language:English
Subjects:
CD34+ cells
HSCT
Immunology
MDSC
regulatory mechanisms
Transplantation Tolerance
Treg
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Summary:Cell-based therapies have been studied extensively in the context of transplantation tolerance induction. The most successful protocols have relied on transfusion of bone marrow prior to the transplantation of a renal allograft. However, it is not clear that stem cells found in bone marrow are required in order to render a transplant candidate immunologically tolerant. Accordingly, mesenchymal stem cells, regulatory myeloid cells, T regulatory cells, and other cell types are being tested as possible routes to tolerance induction, in the absence of donor-derived stem cells. Early data with each of these cell types have been encouraging. However, the induction regimen capable of achieving consistent tolerance, while avoiding unwanted sided effects, and which is scalable to the human patient, has yet to be identified. Here, we present the status of investigations of various tolerogenic cell types and the mechanistic rationale for their use in tolerance induction protocols.
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2016.00087