Comparison of follicular fluid and serum levels of Inhibin A and Inhibin B with calculated indices used as predictive markers of Ovarian Hyperstimulation Syndrome in IVF patients

Ovarian Hyperstimulation Syndrome (OHSS) is a severe health complication observed in some patients undergoing hormonal stimulation during IVF. Presence of OHSS is often associated with a high count of growing follicles responding to FSH hyperstimulation. However, the number of responding follicles m...

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Bibliographic Details
Published in:Reproductive biology and endocrinology 2009-08, Vol.7 (1), p.86-86, Article 86
Main Authors: Moos, Jiri, Rezabek, Karel, Filova, Vanda, Moosova, Martina, Pavelkova, Jana, Peknicova, Jana
Format: Article
Language:English
Subjects:
Adult
Biomarkers - analysis
Biomarkers - blood
Cell Count
Diagnosis
Female
Fertilization in Vitro
Follicular Fluid - chemistry
Follicular Fluid - metabolism
Health Status Indicators
Humans
Inhibin
Inhibins - analysis
Inhibins - blood
Inhibins - metabolism
Ovarian diseases
Ovarian Follicle - pathology
Ovarian Hyperstimulation Syndrome - blood
Ovarian Hyperstimulation Syndrome - diagnosis
Ovarian Hyperstimulation Syndrome - metabolism
Ovarian Hyperstimulation Syndrome - pathology
Physiological aspects
Prognosis
Retrospective Studies
Treatment Outcome
Young Adult
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Summary:Ovarian Hyperstimulation Syndrome (OHSS) is a severe health complication observed in some patients undergoing hormonal stimulation during IVF. Presence of OHSS is often associated with a high count of growing follicles responding to FSH hyperstimulation. However, the number of responding follicles may not be sufficient enough to predict the onset and severity of OHSS. The aim of this study was to find whether follicular fluid (FF) and serum concentrations of Inhibin A and Inhibin B in patients undergoing IVF treatment may serve as a predictor of OHSS status independent of the growing follicles count. Serum and follicular fluid of fifty-three women undertaking the IVF program were separated into four groups according to their OHSS status and growing follicles count and analyzed for serum and FF concentrations of Inhibin A and Inhibin B. The resulting data were combined with clinical and demographic data to calculate indices independent of the growing follicles count. Serum Inhibin A and Inhibin B concentrations showed no significant difference between the severe OHSS group and the control group without OHSS. Moreover, the serum concentrations of Inhibin A and Inhibin B were strongly correlated with the growing follicles count. Their concentrations in the high responders group (>18 follicles) were significantly higher (p < 0.00001, p < 0.0001) when compared with normal and low responders (
ISSN:1477-7827
1477-7827
DOI:10.1186/1477-7827-7-86