The promise of metabolic imaging in diffuse midline glioma

Recent insights into histopathological and molecular subgroups of glioma have revolutionized the field of neuro-oncology by refining diagnostic categories. An emblematic example in pediatric neuro-oncology is the newly defined diffuse midline glioma (DMG), H3 K27–altered. DMG represents a rare tumor...

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Bibliographic Details
Published in:Neoplasia (New York, N.Y.) N.Y.), 2023-05, Vol.39, p.100896-100896, Article 100896
Main Authors: Lovibond, Samantha, Gewirtz, Alexandra N., Pasquini, Luca, Krebs, Simone, Graham, Maya S.
Format: Article
Language:English
Subjects:
Brain Neoplasms - diagnostic imaging
Brain Neoplasms - pathology
Child
Diffuse midline glioma
Glioma - diagnostic imaging
Glioma - pathology
Humans
Imaging
Magnetic Resonance Imaging
Metabolism
MRI
Pediatric Brain Tumor
PET
Positron-Emission Tomography - methods
Prognosis
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Summary:Recent insights into histopathological and molecular subgroups of glioma have revolutionized the field of neuro-oncology by refining diagnostic categories. An emblematic example in pediatric neuro-oncology is the newly defined diffuse midline glioma (DMG), H3 K27–altered. DMG represents a rare tumor with a dismal prognosis. The diagnosis of DMG is largely based on clinical presentation and characteristic features on conventional magnetic resonance imaging (MRI), with biopsy limited by its delicate neuroanatomic location. Standard MRI remains limited in its ability to characterize tumor biology. Advanced MRI and positron emission tomography (PET) imaging offer additional value as they enable non-invasive evaluation of molecular and metabolic features of brain tumors. These techniques have been widely used for tumor detection, metabolic characterization and treatment response monitoring of brain tumors. However, their role in the realm of pediatric DMG is nascent. By summarizing DMG metabolic pathways in conjunction with their imaging surrogates, we aim to elucidate the untapped potential of such imaging techniques in this devastating disease.
ISSN:1476-5586
1522-8002
1476-5586
DOI:10.1016/j.neo.2023.100896