Sarcomatoid malignant pleural mesothelioma associated with anti-Ma2-related paraneoplastic neurological syndrome: A case report

•Paraneoplastic neurological syndrome (PNS) can cause mesothelioma.•PNS is rarely associated with malignant pleural mesothelioma (MPM).•We detected a patient with sarcomatoid MPM with anti-Ma2 autoantibodies.•We diagnosed the first female with anti-Ma2 antibody-associated PNS with MPM.•Overcoming an...

Full description

Saved in:
Bibliographic Details
Published in:Current problems in cancer. Case reports 2023-09, Vol.11, p.100244, Article 100244
Main Authors: Tada, Akio, Kuribayashi, Kozo, Kitajima, Kazuhiro, Nakamura, Akifumi, Yuki, Michiko, Kanemura, Shingo, Shibata, Eisuke, Negi, Yoshiki, Ishigaki, Hirotoshi, Nakajima, Yasuhiro, Takahashi, Ryo, Yokoi, Takashi, Minami, Toshiyuki, Kijima, Takashi
Format: Article
Language:English
Subjects:
Anti-Ma2 antibodies
Cerebellar degeneration
Immunoglobulin therapy
Paraneoplastic syndrome
Sarcomatoid mesothelioma
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:•Paraneoplastic neurological syndrome (PNS) can cause mesothelioma.•PNS is rarely associated with malignant pleural mesothelioma (MPM).•We detected a patient with sarcomatoid MPM with anti-Ma2 autoantibodies.•We diagnosed the first female with anti-Ma2 antibody-associated PNS with MPM.•Overcoming anti-Ma2 antibody-associated PNS may provide long-term survival for MPM. Paraneoplastic neurological syndrome (PNS) is rarely associated with malignant pleural mesothelioma (MPM). We report the first case of sarcomatoid mesothelioma in a 63-year-old female diagnosed with cerebellar degeneration in January 2018. Systemic examination showed right pleura thickening. The pleural biopsy of the mass revealed a sarcomatoid MPM cT3N0M0. In February 2018, anti-Ma2 antibody positivity indicated PNS complicated with MPM. First, cisplatin (75 mg/m2) + pemetrexed (500 mg/m2) chemotherapy was given. For PNS, steroid pulse therapy and high-dose immunoglobulin therapy were administered. MPM may cause anti-Ma2 antibody-related PNS. Early diagnosis and starting anticancer treatment and immunotherapy are critical.
ISSN:2666-6219
2666-6219
DOI:10.1016/j.cpccr.2023.100244