Prevalence of colistin resistance in clinical isolates of Pseudomonas aeruginosa : a systematic review and meta-analysis

The emergence of resistance to colistin, the last resort for treating severe infections caused by , poses a significant threat to public health. This meta-analysis aimed to investigate the prevalence of colistin resistance in clinical isolates of A comprehensive search of MEDLINE (PubMed), Web of Sc...

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Bibliographic Details
Published in:Frontiers in microbiology 2024-10, Vol.15, p.1477836
Main Authors: Narimisa, Negar, Keshtkar, Abbasali, Dadgar-Zankbar, Leila, Bostanghadiri, Narjess, Far, Yasaman Rouein, Shahroodian, Soheila, Zahedi Bialvaei, Abed, Razavi, Shabnam
Format: Article
Language:English
Subjects:
cystic fibrosis
infection prevention
Microbiology
Pseudomonas aeruginosa
public health
treatment regimens
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Summary:The emergence of resistance to colistin, the last resort for treating severe infections caused by , poses a significant threat to public health. This meta-analysis aimed to investigate the prevalence of colistin resistance in clinical isolates of A comprehensive search of MEDLINE (PubMed), Web of Science, and Scopus databases was conducted to identify relevant articles published until December 2023. Subsequently, a meta-analysis was performed using Stata software to examine the pooled prevalence of colistin resistance and to conduct subgroup analyses. A total of 619 studies were included in the meta-analysis, revealing a global prevalence of colistin resistance of 1% among all isolates. Furthermore, cystic fibrosis patients exhibited the highest resistance to colistin, with a prevalence of 7% among the examined diseases. The increase in colistin resistance in in recent years from 2% (in the period of 2006-2010) to 5% (in the period of 2020-2023) underscores the need for implementing infection prevention programs, using appropriate treatment regimens, and disseminating comprehensive information on antimicrobial resistance patterns. These measures are crucial for addressing this growing public health concern.
ISSN:1664-302X
1664-302X
DOI:10.3389/fmicb.2024.1477836