A pigmented calcifying cystic odontogenic tumor associated with compound odontoma: a case report and review of literature

Pigmented intraosseous odontogenic lesions are rare with only 47 reported cases in the English literature. Among them, pigmented calcifying cystic odontogenic tumor, formerly known as calcifying odontogenic cyst, is the most common lesion with 20 reported cases. A case of pigmented calcifying cystic...

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Bibliographic Details
Published in:Head & face medicine 2007-09, Vol.3 (1), p.35-35, Article 35
Main Authors: Han, Phuu P, Nagatsuka, Hitoshi, Siar, Chong H, Tsujigiwa, Hidetsugu, Gunduz, Mehmet, Tamamura, Ryo, Borkosky, Silvia S, Katase, Naoki, Nagai, Noriyuki
Format: Article
Language:English
Subjects:
Adolescent
Case Report
Case studies
Dentistry
Diagnosis
Epithelial Cells - pathology
Health aspects
Humans
Immunohistochemistry
Male
Mandibular Neoplasms - pathology
Melanin
Melanins - analysis
Microscopy, Electron, Transmission
Mouth cancer
Neoplasms, Multiple Primary - pathology
Odontogenic Cyst, Calcifying - pathology
Odontoma - pathology
Risk factors
S100 Proteins - analysis
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Summary:Pigmented intraosseous odontogenic lesions are rare with only 47 reported cases in the English literature. Among them, pigmented calcifying cystic odontogenic tumor, formerly known as calcifying odontogenic cyst, is the most common lesion with 20 reported cases. A case of pigmented calcifying cystic odontogenic tumor associated with odontoma occurring at the mandibular canine-premolar region of a young Japanese boy is presented with radiographic, and histological findings. Special staining, electron microscopic study and immunohistochemical staining were also done to characterize the pigmentation. The pigments in the lesion were confirmed to be melanin by Masson-Fontana staining and by transmission electron microscopy. The presence of dendritic melanocytes within the lesion was also demonstrated by S-100 immunostaining. The present case report of pigmented calcifying cystic odontogenic tumor associated with odontoma features a comprehensive study on melanin and melanocytes, including histochemical, immunohistochemical and transmission electron microscopic findings.
ISSN:1746-160X
1746-160X
DOI:10.1186/1746-160X-3-35