Analgesic efficacy of tapentadol in chronic joint disorders in horses: plasma serotonin concentration and adrenocortical response as biomarkers of pain-induced stress

The study aimed to evaluate the analgesic efficacy of tapentadol in horses, by determining plasma serotonin concentration and adrenocortical response, as biomarkers of pain stress in chronic joint disorders. Thirty-six horses (20 females and 16 males) were divided into three groups of 12 subjects ea...

Full description

Saved in:
Bibliographic Details
Published in:Frontiers in veterinary science 2024-12, Vol.11, p.1505398
Main Authors: Costa, Giovanna Lucrezia, Tabbì, Marco, Bruschetta, Giuseppe, Spadola, Filippo, Leonardi, Fabio, Bruno, Fabio, Iannelli, Nicola Maria, Licata, Patrizia, Macrì, Francesco, Passino, Eraldo Sanna, Macrì, Daniele, Interlandi, Claudia
Format: Article
Language:English
Subjects:
biomarkers
cortisol
osteoarthritis
pain-induced stress
serotonin
tapentadol
Veterinary Science
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The study aimed to evaluate the analgesic efficacy of tapentadol in horses, by determining plasma serotonin concentration and adrenocortical response, as biomarkers of pain stress in chronic joint disorders. Thirty-six horses (20 females and 16 males) were divided into three groups of 12 subjects each: group A, osteoarthritis (OA), grade 3-4 lameness; group B, OA, grade 5 lameness; and group C, no OA, no lameness, were enrolled. The orthopedic examination included flexion tests, and radiological and ultrasound examinations. The degree of lameness has been estimated from 0 to 5 according to the American Association of Equine Practitioners (AAEPs). Heart and respiratory rates (HR and RR) and blood pressure were recorded. Serotonin concentration and circulating cortisol levels were determined at baseline and the end of every week for 4 weeks. Biochemical parameters were recorded at baseline and the end of treatment with tapentadol. Subjects with OA were treated with tapentadol 0.5 mg kg . The response to painful stimulus on flexion tests was evaluated using the modified numeric pain rating scale (modified NRS 0-7) from baseline and the cumulative pain score (CPS 0-4) after the first week of treatment with tapentadol. The lameness decreased throughout the timeline in both groups (score from 3-4 to 1 in group A and score from 5 to 1 in group B) (  
ISSN:2297-1769
2297-1769
DOI:10.3389/fvets.2024.1505398