Protein biomarkers of disease progression in patients with systemic sclerosis associated interstitial lung disease

Systemic sclerosis is a rare connective tissue disease; and interstitial lung disease (SSc–ILD) is associated with significant morbidity and mortality. There are no clinical, radiologic features, nor biomarkers that identify the specific time when patients are at risk for progression at which the be...

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Published in:Scientific reports 2023-05, Vol.13 (1), p.8645-9, Article 8645
Main Authors: Cerro-Chiang, Giuliana, Ayres, Matthew, Rivas, Alejandro, Romero, Tahmineh, Parker, Sarah J., Mastali, Mitra, Elashoff, David, Chen, Peter, Van Eyk, Jennifer E., Wolters, Paul J., Boin, Francesco, Zaman, Tanzira
Format: Article
Language:English
Subjects:
692/308/53/2423
692/4023/1670/122/1801
692/699/1785
Autoimmunity
Biomarkers
Connective tissue diseases
Disease Progression
Heterogeneity
Humanities and Social Sciences
Humans
Immunosuppressive Agents - therapeutic use
Inflammation
Lung
Lung diseases
Lung Diseases, Interstitial - complications
Mass spectrometry
Mass spectroscopy
Metabolic pathways
Morbidity
multidisciplinary
Patients
Principal components analysis
Proteins
Science
Science (multidisciplinary)
Scleroderma
Scleroderma, Systemic
Serum proteins
Systemic sclerosis
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Summary:Systemic sclerosis is a rare connective tissue disease; and interstitial lung disease (SSc–ILD) is associated with significant morbidity and mortality. There are no clinical, radiologic features, nor biomarkers that identify the specific time when patients are at risk for progression at which the benefits from treatment outweigh the risks. Our study aimed to identify blood protein biomarkers associated with progression of interstitial lung disease in patients with SSc–ILD using an unbiased, high-throughput approach. We classified SSc–ILD as progressive or stable based on change in forced vital capacity over 12 months or less. We profiled serum proteins by quantitative mass spectrometry and analyzed the association between protein levels and progression of SSc–ILD via logistic regression. The proteins associated with at a p value of 
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-023-35840-y