Anticancer Applications of Essential Oils Formulated into Lipid-Based Delivery Nanosystems

The use of natural compounds is becoming increasingly popular among patients, and there is a renewed interest among scientists in nature-based bioactive agents. Traditionally, herbal drugs can be taken directly in the form of teas/decoctions/infusions or as standardized extracts. However, the disadv...

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Bibliographic Details
Published in:Pharmaceutics 2022-12, Vol.14 (12), p.2681
Main Authors: Jampilek, Josef, Kralova, Katarina
Format: Article
Language:English
Subjects:
Antimitotic agents
Antineoplastic agents
Aromatherapy
Bioavailability
Cancer therapies
Drug delivery systems
Drugs
Essences and essential oils
essential oils
Folk medicine
Health aspects
herbal drugs
Homogenization
Lipids
liposomes
Materials
Metabolites
Nanoemulsions
Nanomedicine
Nanoparticles
nanostructured lipid carriers
Oils & fats
Particle size
Pharmaceuticals
Review
solid lipid nanoparticles
Testing
Vehicles
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Summary:The use of natural compounds is becoming increasingly popular among patients, and there is a renewed interest among scientists in nature-based bioactive agents. Traditionally, herbal drugs can be taken directly in the form of teas/decoctions/infusions or as standardized extracts. However, the disadvantages of natural compounds, especially essential oils, are their instability, limited bioavailability, volatility, and often irritant/allergenic potential. However, these active substances can be stabilized by encapsulation and administered in the form of nanoparticles. This brief overview summarizes the latest results of the application of nanoemulsions, liposomes, solid lipid nanoparticles, and nanostructured lipid carriers used as drug delivery systems of herbal essential oils or used directly for their individual secondary metabolites applicable in cancer therapy. Although the discussed bioactive agents are not typical compounds used as anticancer agents, after inclusion into the aforesaid formulations improving their stability and bioavailability and/or therapeutic profile, they indicated anti-tumor activity and became interesting agents with cancer treatment potential. In addition, co-encapsulation of essential oils with synthetic anticancer drugs into nanoformulations with the aim to achieve synergistic effect in chemotherapy is discussed.
ISSN:1999-4923
1999-4923
DOI:10.3390/pharmaceutics14122681