The Mediterranean red alga Asparagopsis: a source of compounds against Leishmania

Crude extracts and column fractions from the red algae Asparagopsis taxiformis and A. armata from the Strait of Messina (Italy) were screened for the production of antimicrobial compounds. Extracts from both species revealed remarkable antiprotozoal activity against Leishmania, revealing such algae...

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Bibliographic Details
Published in:Marine drugs 2009-08, Vol.7 (3), p.361-366
Main Authors: Genovese, Giuseppa, Tedone, Laura, Hamann, Mark T, Morabito, Marina
Format: Article
Language:English
Subjects:
Amphotericin B - administration & dosage
Amphotericin B - pharmacology
antiprotozoal products
Asparagopsis armata
Asparagopsis taxiformis
halogenated metabolites
Inhibitory Concentration 50
Italy
Leishmania
Leishmania - drug effects
Leishmaniasis - drug therapy
marine natural products
Mediterranean Sea
Pentamidine - administration & dosage
Pentamidine - pharmacology
Rhodophyta - chemistry
Trypanocidal Agents - administration & dosage
Trypanocidal Agents - isolation & purification
Trypanocidal Agents - pharmacology
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Summary:Crude extracts and column fractions from the red algae Asparagopsis taxiformis and A. armata from the Strait of Messina (Italy) were screened for the production of antimicrobial compounds. Extracts from both species revealed remarkable antiprotozoal activity against Leishmania, revealing such algae as a great source of natural antiprotozoal products.
ISSN:1660-3397
1660-3397
DOI:10.3390/md7030361