Characteristics, Outcomes, and Treatment of Heart Failure With Improved Ejection Fraction

Background Many patients with heart failure ( HF ) with reduced ejection fraction ( HF r EF ) experience improvement or recovery of left ventricular ejection fraction ( LVEF ). Data on clinical characteristics, outcomes, and medical therapy in patients with HF with improved ejection fraction (HFiEF)...

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Published in:Journal of the American Heart Association 2019-03, Vol.8 (6), p.e011077
Main Authors: Park, Chan Soon, Park, Jin Joo, Mebazaa, Alexandre, Oh, Il-Young, Park, Hyun-Ah, Cho, Hyun-Jai, Lee, Hae-Young, Kim, Kye Hun, Yoo, Byung-Su, Kang, Seok-Min, Baek, Sang Hong, Jeon, Eun-Seok, Kim, Jae-Joong, Cho, Myeong-Chan, Chae, Shung Chull, Oh, Byung-Hee, Choi, Dong-Ju
Format: Article
Language:English
Subjects:
Adrenergic beta-Antagonists - therapeutic use
Aged
Cause of Death - trends
Echocardiography
Female
Follow-Up Studies
heart failure
Heart Failure - drug therapy
Heart Failure - mortality
Heart Failure - physiopathology
Heart Ventricles - diagnostic imaging
Heart Ventricles - physiopathology
Hospitalization - trends
Humans
improved ejection fraction
Male
Middle Aged
Mineralocorticoid Receptor Antagonists - therapeutic use
mortality
Original Research
Propensity Score
Prospective Studies
Registries
Republic of Korea - epidemiology
Stroke Volume - physiology
Survival Rate - trends
Time Factors
Treatment Outcome
Ventricular Function, Left - physiology
β‐blockers
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Summary:Background Many patients with heart failure ( HF ) with reduced ejection fraction ( HF r EF ) experience improvement or recovery of left ventricular ejection fraction ( LVEF ). Data on clinical characteristics, outcomes, and medical therapy in patients with HF with improved ejection fraction (HFiEF) are scarce. Methods and Results Of 5625 consecutive patients hospitalized for acute HF in the KorAHF (Registry [Prospective Cohort] for Heart Failure in Korea) study, 5103 patients had baseline echocardiography and 2302 patients had follow-up echocardiography at 12 months. HF phenotypes were defined as persistent HF r EF ( LVEF ≤40% at baseline and at 1-year follow-up), HF i EF ( LVEF ≤40% at baseline and improved up to 40% at 1-year follow-up), HF with midrange ejection fraction (LVEF between 40% and
ISSN:2047-9980
2047-9980
DOI:10.1161/JAHA.118.011077