Antifungal activity of synthetic antiseptics and natural compounds against Candida dubliniensis before and after in vitro fluconazole exposure

This study evaluated the susceptibilities of oral candidiasis-derived Candida albicans, fluconazole-resistant (FR) Candida dubliniensis, and fluconazole-susceptible (FS) C. dubliniensis to synthetic antiseptics [chlorhexidine gluconate (CHX), cetylpyridinium chloride (CPC), and triclosan (TRC)] and...

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Bibliographic Details
Published in:Revista da Sociedade Brasileira de Medicina Tropical 2017-01, Vol.50 (1), p.75-79
Main Authors: Reginato, Cássia Franco, Bandeira, Laíssa Arévalo, Zanette, Régis Adriel, Santurio, Janio Morais, Alves, Sydney Hartz, Danesi, Cristiane Cademartori
Format: Article
Language:English
Subjects:
Anti-Infective Agents, Local - pharmacology
Antifungal activity
Antifungal agents
Antifungal Agents - pharmacology
Antimicrobial agents
Antiseptics
Candida - classification
Candida - drug effects
Candida - isolation & purification
Candida albicans - drug effects
Candida dubliniensis
Candidiasis
Carvacrol
Cetylpyridinium - pharmacology
Cetylpyridinium chloride
Chlorhexidine
Chlorhexidine - pharmacology
Chlorides
Eugenol
Eugenol - pharmacology
Fluconazole
Fluconazole - pharmacology
Fungal infections
Fungi
Humans
Microbial Sensitivity Tests
Pharmacology
Susceptibility
Thymol
Thymol - pharmacology
Triclosan
Triclosan - pharmacology
TROPICAL MEDICINE
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Summary:This study evaluated the susceptibilities of oral candidiasis-derived Candida albicans, fluconazole-resistant (FR) Candida dubliniensis, and fluconazole-susceptible (FS) C. dubliniensis to synthetic antiseptics [chlorhexidine gluconate (CHX), cetylpyridinium chloride (CPC), and triclosan (TRC)] and natural compounds (carvacrol, eugenol and thymol). Susceptibility tests were performed based on the M27-A3 reference method. The fluconazole-resistant C. dubliniensis strains were obtained after prolonged in vitro exposure to increasing fluconazole concentrations. The geometric mean values for minimum inhibitory concentrations and minimum fungicidal concentrations were compared among the groups. Fluconazole-susceptible C. dubliniensis was more sensitive to CPC and TRC than FR C. dubliniensis and C. albicans were. However, eugenol and thymol were more active against FR C. dubliniensis. The fungicidal activities of CHX and TRC were similar for the three groups, and FR C. dubliniensis and C. albicans had similar sensitivities to CPC. The resistance of C. dubliniensis to fluconazole affects its sensitivity the synthetic antiseptics and natural compounds that were tested.
ISSN:0037-8682
1678-9849
1678-9849
DOI:10.1590/0037-8682-0461-2016