Injectable thermosensitive hydrogel composite with surface-functionalized calcium phosphate as raw materials

In this study, L-lactide was used to modify the tricalcium phosphate (β-TCP) and tetracalcium phosphate (TTCP) surface which can form functionalized poly(l-lactic acid) (PLLA)-grafted β-TCP (g-β-TCP) and PLLA-grafted TTCP (g-TTCP) particles. The g-β-TCP and g-TTCP obtained were incorporated into a P...

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Bibliographic Details
Published in:International journal of nanomedicine 2014-01, Vol.9 (Issue 1), p.615-626
Main Authors: Fan, RangRang, Deng, XiaoHui, Zhou, LiangXue, Gao, Xiang, Fan, Min, Wang, YueLong, Guo, Gang
Format: Article
Language:English
Subjects:
biocompatibility
Biocompatible Materials - administration & dosage
Biocompatible Materials - chemistry
Calcium phosphate
Calcium Phosphates - administration & dosage
Calcium Phosphates - chemistry
Composite materials
Drug delivery systems
Drugs
Hot Temperature
Hydrogel, Polyethylene Glycol Dimethacrylate - administration & dosage
Hydrogel, Polyethylene Glycol Dimethacrylate - chemistry
injectable
Injections
Materials Testing
Nanoparticles
Original Research
Physiological aspects
surface functionalization
Surface Properties
thermosensitivity
Tissue Engineering - methods
Vehicles
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Summary:In this study, L-lactide was used to modify the tricalcium phosphate (β-TCP) and tetracalcium phosphate (TTCP) surface which can form functionalized poly(l-lactic acid) (PLLA)-grafted β-TCP (g-β-TCP) and PLLA-grafted TTCP (g-TTCP) particles. The g-β-TCP and g-TTCP obtained were incorporated into a PEG-PCL-PEG (PECE) matrix to prepare injectable thermosensitive hydrogel composites. The morphology of the hydrogel composites showed that the g-β-TCP and g-TTCP particles dispersed homogeneously into the polymer matrix, and each hydrogel composite had a three-dimensional network structure. Rheologic analysis showed that the composite had good thermosensitivity. Changes in calcium concentration and pH in simulated body fluid solutions confirmed the feasibility of surface-functionalized calcium phosphate for controlled release of calcium. All the results indicate that g-β-TCP/PECE and g-TTCP/PECE hydrogels might be a promising protocol for tissue engineering.
ISSN:1178-2013
1176-9114
1178-2013
DOI:10.2147/IJN.S52689